环(组氨酰-脯氨酰)
|
|
|
- CAS号:
- 53109-32-3
- 英文名:
- CYCLO(-HIS-PRO)
- 英文别名:
- Cyclo(HP);Cyclo(Pro-His);CYCLO(-HIS-PRO);HIS-PRO, CYCLIC;Cyclo-Pro-His-HO;CYCLO(HIS-PRO), >99%;Cyclo(histidyl-proline);Protirelin EP Impurity E;Cyclo(L-histidyl-L-proline);Nebivolol Impurity 10 Monomer
- 中文名:
- 环(组氨酰-脯氨酰)
- 中文别名:
- 普罗瑞林EP杂质E;环(组氨酰-脯氨酰);化合物CYCLO(HIS-PRO);CYCLO(HIS-PRO) (CYCLO(HISTIDYL-PROLINE));(3S,8AS)-3-[(4-咪唑基)甲基]六氢吡咯并[1,2-A]吡嗪-1,4-二酮;(3S,8AS)-六氢-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮
- CBNumber:
- CB8279260
- 分子式:
- C11H14N4O2
- 分子量:
- 234.25
- MOL File:
- 53109-32-3.mol
|
|
|
环(组氨酰-脯氨酰)化学性质
-
熔点:
-
162-164 °C
-
|
-
沸点:
-
659.3±48.0 °C(Predicted)
-
|
-
密度:
-
1.41±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
-
|
-
形态:
-
A neat oil
-
|
-
酸度系数(pKa):
-
12.73±0.40(Predicted)
-
|
环(组氨酰-脯氨酰)性质、用途与生产工艺
Cyclo(his-pro) (Cyclo(histidyl-proline)) 是一种具有口服活性的，结构上与促甲状腺激素释放激素相关的环状二肽。Cyclo(his-pro) 可以抑制 NF-κB 核积累。Cyclo(his-pro) 可以穿越脑血屏障并影响多种炎症和应激反应。
|
NF-κB
|
Human Endogenous Metabolite
|
cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.
Western Blot Analysis
|
Cell Line:
|
PC12 cells
|
|
Concentration:
|
50 μM
|
|
Incubation Time:
|
1, 2, 4, 8, 24, 48 hours
|
|
Result:
|
Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation.
|
Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.
|
Animal Model:
|
Sixty two/three month-old male C57BL/6 mice (25-30 g)
|
|
Dosage:
|
1.8 mg/ear
|
|
Administration:
|
Topical application on the right ear; 30 min prior to TPA
|
|
Result:
|
Reduced TPA-induced ear oedema.
|
环(组氨酰-脯氨酰)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101402 | 环(组氨酰-脯氨酰)
Cyclo(his-pro) | 53109-32-3 | 1mg | 500元 |
| 2024/04/30 | HY-101402 | 环(组氨酰-脯氨酰)
Cyclo(his-pro) | 53109-32-3 | 5mg | 900元 |
53109-32-3, 环(组氨酰-脯氨酰) 相关搜索:
- 高端化学
- 目录肽
- 抑制剂
- 标准品
- 多肽中间体
- 氨基酸中间体
- BioChemical
- Amino Acids and Peptides
- Biochemicals and Reagents
- TRH
- Releasing Factors
- Peptides
- 普罗瑞林EP杂质E
- (3S,8AS)-3-[(4-咪唑基)甲基]六氢吡咯并[1,2-A]吡嗪-1,4-二酮
- CYCLO(HIS-PRO) (CYCLO(HISTIDYL-PROLINE))
- 化合物CYCLO(HIS-PRO)
- (3S,8AS)-六氢-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮
- 环(组氨酰-脯氨酰)
- 53109-32-3
- Cyclo(Pro-His)
- Nebivolol Impurity 10 Monomer
- (3S,8aS)-3-[(4-Imidazolyl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
- Cyclo(HP)
- Endogenous Metabolite,active,orally,inflammatory,inhibit,tyreotropin-releasing,stress,NF-κB,Cyclo(his-pro),hormone,Nuclear factor-κB,cyclic,Cyclo(hispro),Histidylproline diketopiperazine,Cyclo(histidyl-proline),dipeptide,Cyclo(his pro),Inhibitor,Nuclear factor-kappaB,responses
- Cyclo(his-pro) (Cyclo(histidyl-proline))
- (3S,8aS)-3-(1H-Imidazol-4-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
- Cyclo(L-histidyl-L-proline)
- 3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
- Protirelin EP Impurity E
- Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S,8aS)-
- Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine, >99%
- CYCLO(HIS-PRO), >99%
- CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE
- Cyclo(histidyl-proline)
- CYCLO(-HIS-PRO)
- HIS-PRO, CYCLIC
- Cyclo-Pro-His-HO
- histidylproline dioxopiperazine
- Histidylproline diketopiperazine
- (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione