1779796-27-8
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- CAS号:
- 1779796-27-8
- 英文名:
- LY2365109 (hydrochloride)
- 英文别名:
- LY2365109 HCl;neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit
- 中文名:
- 1779796-27-8
- 中文别名:
- LY2365109盐酸盐;2-((2-(4-(苯并[D][1,3]二氧杂戊环-5-基)-2-(叔丁基)苯氧基)乙基)(甲基)氨基)乙酸盐酸盐
- CBNumber:
- CB83146615
- 分子式:
- C22H28ClNO5
- 分子量:
- 421.92
- MOL File:
- 1779796-27-8.mol
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1779796-27-8化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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Soluble to 100 mM in DMSO and to 50 mM in ethanol
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1779796-27-8性质、用途与生产工艺
LY2365109 hydrochloride 是一种高效、选择性的 GlyT1 抑制剂，抑制过表达 hGlyT1 细胞摄取谷氨酸的 IC50 值为 15.8 nM.
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hGlyT1
15.8 nM nM (IC
50
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LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
LY2365109 hydrochloride increases seizure thresholds in mice.
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Animal Model:
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Male Sprague-Dawley rats (250-300 g)
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Dosage:
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0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:
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Oral administration
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Result:
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Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
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1779796-27-8
上下游产品信息
上游原料
下游产品
1779796-27-8, 1779796-27-8 相关搜索:
- 药靶配体
- 2-((2-(4-(苯并[D][1,3]二氧杂戊环-5-基)-2-(叔丁基)苯氧基)乙基)(甲基)氨基)乙酸盐酸盐
- LY2365109盐酸盐
- 1779796-27-8
- neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit
- LY2365109 HCl