8-NITROTRYPTANTHRIN
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- CAS号:
- 77603-42-0
- 英文名:
- 8-Nitrotryptanthrin
- 英文别名:
- GNF-PF-3777;8-Nitrotryptanthrin;GNF-PF-3777 (8-Nitrotryptanthrin);8-Nitroindolo[2,1-b]quinazoline-6,12-dione;Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-;GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO)
- 中文名:
- 8-NITROTRYPTANTHRIN
- 中文别名:
- 化合物GNF-PF-3777;8-硝基吲哚并[2,1-B]喹唑啉-6,12-二酮
- CBNumber:
- CB83155055
- 分子式:
- C15H7N3O4
- 分子量:
- 293.23
- MOL File:
- 77603-42-0.mol
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8-NITROTRYPTANTHRIN化学性质
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熔点:
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>250 °C
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沸点:
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551.2±52.0 °C(Predicted)
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密度:
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1.67±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO:4.2(Max Conc. mg/mL);14.32(Max Conc. mM)
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形态:
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A crystalline solid
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酸度系数(pKa):
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-7.55±0.20(Predicted)
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8-NITROTRYPTANTHRIN性质、用途与生产工艺
GNF-PF-3777 (8-Nitrotryptanthrin) 是一种有效的人吲哚胺2，3-双加氧酶 2 (hIDO2) 抑制剂，有效降低 IDO2 活性，Ki 值为 0.97 μM。
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rhIDO2
1.8 μM (IC
50
)
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rhIDO2
0.97 μM (Ki)
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The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC
50
values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC
50
of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.
8-NITROTRYPTANTHRIN
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100687 | 8-NITROTRYPTANTHRIN
GNF-PF-3777 | 77603-42-0 | 1mg | 900元 |
| 2024/01/25 | HY-100687 | 8-NITROTRYPTANTHRIN
GNF-PF-3777 | 77603-42-0 | 5mg | 2500元 |
77603-42-0, 8-NITROTRYPTANTHRIN 相关搜索:
- 化合物GNF-PF-3777
- 8-硝基吲哚并[2,1-B]喹唑啉-6,12-二酮
- 77603-42-0
- 8-Nitroindolo[2,1-b]quinazoline-6,12-dione
- GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO)
- GNF-PF-3777 (8-Nitrotryptanthrin)
- Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-
- GNF-PF-3777
- 8-Nitrotryptanthrin