妥布特罗
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- CAS号:
- 41570-61-0
- 英文名:
- Tulobuterol
- 英文别名:
- Tulobutero;TULOBUTEROL BASE;HN 078;Sekinarin;Tulobuten;Tulobunist;TULOBUTEROL;Tulobuterol API;Tulobuterol Bane;Tulobuterol USP/EP/BP
- 中文名:
- 妥布特罗
- 中文别名:
- 妥布特罗;妥洛特罗;妥布特罗 标准品;妥布特罗溶液,100PPM;alpha-[(叔丁基氨基)甲基]-邻氯苯甲醇
- CBNumber:
- CB8320201
- 分子式:
- C12H18ClNO
- 分子量:
- 227.73
- MOL File:
- 41570-61-0.mol
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妥布特罗化学性质
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熔点:
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89-91°C
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沸点:
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338.2±27.0 °C(Predicted)
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密度:
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1.098±0.06 g/cm3(Predicted)
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RTECS号:
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DA4734170
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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13.62±0.20(Predicted)
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形态:
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Solid
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颜色:
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White to Off-White
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CAS 数据库:
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41570-61-0(CAS DataBase Reference)
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妥布特罗性质、用途与生产工艺
Tulobuterol (C-78 free base) 是一种长效的 β2 肾上腺素受体 (β2-adrenoceptor) 激动剂，可减少慢性阻塞性肺疾病和支气管哮喘的发作频率。Tulobuterol 也是一种拟交感神经药，用作透皮贴剂，可增加正常的横膈膜肌肉力量。
Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with Tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.
RT-PCR
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Cell Line:
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Human tracheal epithelial cells infected with RV14
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Concentration:
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0.1 μM
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Incubation Time:
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24 hours or 72 hours
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Result:
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Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.
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In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after
E. coli
endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.
妥布特罗
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B1810 | 妥布特罗
Tulobuterol | 41570-61-0 | 50mg | 700元 |
| 2024/01/25 | HY-B1810 | 妥布特罗
Tulobuterol | 41570-61-0 | 100mg | 1200元 |
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41570-61-0, 妥布特罗 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- Amines
- API
- 药靶配体
- 医药原料
- 医药 平喘药
- 瘦肉精类
- C12H18ClNO
- 妥布特罗 标准品
- 妥布特罗溶液,100PPM
- alpha-[(叔丁基氨基)甲基]-邻氯苯甲醇
- 妥布特罗
- 妥洛特罗
- 41570-61-0
- Tulobutero
- TULOBUTEROL BASE
- 1-(2-chlorophenyl)-2-[[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]amino]ethanol
- Tulobuterol USP/EP/BP
- Benzenemethanol, 2-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-
- Tulobuterol, racemic mixture
- Tulobuterol（mixture of isomers）
- 2-(tert-ButylaMino)-1-(2-chlorophenyl)ethanol
- Tulobuterol API
- o-Chloro-α-[(tert-butylaMino)Methyl]benzyl Alcohol
- 2-Chloro-α-[[(1,1-diMethylethyl)aMino]Methyl]benzeneMethanol
- α-[(tert-Butylamino)methyl]-2-chlorobenzenemethanol
- Tulobuten
- Tulobunist
- Sekinarin
- 2-(tert-Butylamino)-1-(o-chlorophenyl)ethanol
- 2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
- Tulobuterol (base and/or unspecified salts)
- Tulobuterol Bane
- o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol
- HN 078
- Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]- (9CI)
- 2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethano
- alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol
- Tulobuterol(baseandorunspecifiedsalt)
- TulobuterolHcl56776-01-3/Base
- TULOBUTEROL