盐酸去甲维拉帕米
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- CAS号:
- 67812-42-4
- 英文名:
- NORVERAPAMIL HYDROCHLORIDE
- 英文别名:
- NORVERAPAMIL HCL;D591 hydrochloride;Verapamil EP Impurity J;Verapamil Impurity J HCl;NORVERAPAMIL HYDROCHLORIDE;Verapamil EP Impurity J HCl;(+)Norverapamil hydrochloride;(+/-)-Norverapamil hydrochloride;n-nor-(±)-verapamil hydrochloride;(±)-Norverapamill hydrochloride solution
- 中文名:
- 盐酸去甲维拉帕米
- 中文别名:
- 去甲维拉帕米;维拉帕米杂质J;盐酸去甲维拉帕;盐酸去甲维拉帕米;盐酸去甲维他帕米;去甲维拉帕米盐酸盐;N-去甲维拉帕米盐酸盐;维拉帕米杂质J (EP);维拉帕米EP杂质J盐酸盐;盐酸去甲维拉帕米[干冰运输]
- CBNumber:
- CB8331256
- 分子式:
- C26H37ClN2O4
- 分子量:
- 477.04
- MOL File:
- 67812-42-4.mol
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盐酸去甲维拉帕米性质、用途与生产工艺
Norverapamil hydrochloride，是 Verapamil 的 N-去甲基代谢物，是一种钙通道 (L-type calcium channel) 阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
Calcium channel blocker
P-glycoprotein (P-gp) inhibitor
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil.
Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.
Norverapamil hydrochloride (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng▪h/ml, and 41.6 ng/mL, respectively.
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Animal Model:
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Male Sprague-Dawley rats
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Dosage:
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9 mg/kg (Pharmacokinetic Study)
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Administration:
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Oral administration
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Result:
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t
1/2
=9.4 hours;
AUC=260 ng▪h/mL;
C
max
=41.6 ng/mL.
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盐酸去甲维拉帕米
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-100750 | 盐酸去甲维拉帕米
Norverapamil hydrochloride | 67812-42-4 | 2mg | 950元 |
| 2024/01/25 | HY-100750 | 盐酸去甲维拉帕米
Norverapamil hydrochloride | 67812-42-4 | 5mg | 1550元 |
67812-42-4, 盐酸去甲维拉帕米 相关搜索:
蝙蝠葛碱 奎尼丁 吡西卡尼 盐酸利多卡因 盐酸维拉帕米 S-维拉帕米 3',4'-二甲氧基异苯丁酮 N-甲基l-N-(3-氯丙基)-3,4-二甲氧基苯乙胺 3-甲基-2-(3,4-二甲氧基苯基)丁腈 ALPHA-[3-[[2-(3,4-二甲氧基苯基)乙基]甲基氨基]丙基]-ALPHA-乙基-3,4-二甲氧基-苯乙腈单盐酸盐 维拉帕米杂质A 3,4-二甲氧基-N,N-二甲基苯乙胺盐酸盐 维拉帕米杂质D N,N'-二[2-(3,4-二甲氧基苯基)乙基]-N,N'-二甲基-1,3-丙二胺二盐酸盐 3,4-二甲氧基-N-甲基苯乙胺盐酸盐 维拉帕米杂质O 盐酸去氯羟嗪 维拉帕米相关物质B
- Various Metabolites and Impurities
- Metabolites
- 原料药
- 维拉帕米杂质
- 杂质对照品
- 医药原料药
- 合成
- BioChemical
- Calcium Channel Modulators
- Cell Biology
- Cell Signaling and Neuroscience
- Voltage-gated Ion Channels
- Ion Channels
- C26H36N2O4HCl
- 670018-85-3
- 盐酸去甲维拉帕
- 维拉帕米EP杂质J盐酸盐
- 维拉帕米 EP 杂质 J HCL
- 盐酸去甲维拉帕米[干冰运输]
- VERAPAMIL EP IMPURITY J HCL (N-DESMETHYL VERAPAMIL HCL)
- 维拉帕米杂质J
- 维拉帕米杂质J (EP)
- N-去甲维拉帕米盐酸盐
- 盐酸去甲维他帕米
- 去甲维拉帕米盐酸盐
- 去甲维拉帕米
- 盐酸去甲维拉帕米(N-去甲 盐酸维拉帕米)
- 盐酸去甲维拉帕米
- 67812-42-4
- (+)Norverapamil hydrochloride
- MDR1,CD243,Inhibitor,mycobacterial,Norverapamil,M. tuberculosis,Multidrug resistance protein 1,Ca2+ channels,metabolite,(±)-Norverapamil,P-gp,Calcium Channel,efflux,Ca channels,Drug Metabolite,P-glycoprotein,inhibit,ABCB1,Cluster of differentiation 243,D 591,Norverapamil hydrochloride,pumps,D-591,D591,Pgp
- 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile,hydrochloride
- D591 hydrochloride
- (±)-NORVERAPAMIL HYDROCHLORIDE;D591 HYDROCHLORIDE
- Verapamil Impurity J HCl
- Norverapamil HydrochlorideQ: What is
Norverapamil Hydrochloride Q: What is the CAS Number of
Norverapamil Hydrochloride Q: What is the storage condition of
Norverapamil Hydrochloride Q: What are the applications of
Norverapamil Hydrochloride
- Verapamil EP Impurity J HCl
- (+/-)-Norverapamil hydrochloride
- (+/-)-Norverapamill hydrochloride solution
- Verapamil EP Impurity J HCl (N-Desmethyl Verapamil HCl)
- Verapamil Impurity 10（Verapamil EP Impurity J）
- Verapamil EP Impurity J
- (±)-Norverapamill hydrochloride solution
- NorverapaMil HCl (N-DesMethyl VerapaMil HCl)
- a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
- (+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH
- α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile
- n-nor-(±)-verapamil hydrochloride
- a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- benzeneacetonitril
- (+/-)-VERAPAMIL, NOR-METHYL-, HYDROCHLORIDE
- NORVERAPAMIL HYDROCHLORIDE
- NORVERAPAMIL HCL