网站主页 >> CAS数据库列表 >> 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
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- CAS号:
- 1644443-47-9
- 英文名:
- Autophinib
- 英文别名:
- CS-2834;Autophinib;PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor;6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine;6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE;4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
- 中文名:
- 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
- 中文别名:
- 化合物AUTOPHINIB;AUTOPHINIB,VPS34抑制剂;AUTOPHAGY抑制剂(AUTOPHINIB);6-氯-N-(5-甲基-1H-吡唑-3-基)-2-(4-硝基苯氧基)嘧啶-4-胺
- CBNumber:
- CB83344886
- 分子式:
- C14H11ClN6O3
- 分子量:
- 346.73
- MOL File:
- 1644443-47-9.mol
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6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE化学性质
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沸点:
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640.6±65.0 °C(Predicted)
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密度:
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1.547±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO:13.98(Max Conc. mg/mL);40.32(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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13.78±0.10(Predicted)
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颜色:
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Light yellow to yellow
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6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE性质、用途与生产工艺
Autophinib是有效的自噬 (autophagy)抑制剂,在饥饿诱导的自噬试验和rapamycin诱导的自噬试验中,其IC50分别为90 nM和40 nM。它还是Vps34的抑制剂,IC50为19 nM。
Target | Value |
Vps34
()
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19 nM
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Autophagy
(Rapamycin induced)
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40 nM
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Autophagy
(starvation-induced)
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90 nM
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在喂养和饥饿条件下,Autophinib抑制自噬体的积累,但不影响自噬体的数量。所以,Autophinib不是一种晚期自噬抑制剂,而是抑制自噬体的形成。Autophinib能够靶向VPS34,但不靶向其他脂质激酶如mTOR和TBK1。Autophinib可能是ATP竞争性的,在细胞溶解产物中靶向VPS34、诱导相应的细胞表型。
6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101920 | 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE Autophinib | 1644443-47-9 | 2mg | 600元 |
2024/08/19 | HY-101920 | 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE Autophinib | 1644443-47-9 | 5mg | 900元 |
6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
生产厂家
1644443-47-9, 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE 相关搜索:
- 药靶配体
- 细胞生物学试剂
- AUTOPHINIB,VPS34抑制剂
- 化合物AUTOPHINIB
- 6-氯-N-(5-甲基-1H-吡唑-3-基)-2-(4-硝基苯氧基)嘧啶-4-胺
- AUTOPHAGY抑制剂(AUTOPHINIB)
- 1644443-47-9
- PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor
- 4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
- CS-2834
- 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
- 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
- Autophinib