288591-93-5
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- CAS号:
- 288591-93-5
- 英文名:
- Leu-AMS
- 英文别名:
- Leu-AMS;Leu AMS,LeuAMS;Adenosine, 5'-[[(2S)-2-amino-4-methyl-1-oxopentyl]sulfamate]
- 中文名:
- 288591-93-5
- 中文别名:
- 化合物 T11840
- CBNumber:
- CB83386493
- 分子式:
- C16H25N7O7S
- 分子量:
- 459.48
- MOL File:
- 288591-93-5.mol
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288591-93-5化学性质
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密度:
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1.83±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:49.17(Max Conc. mg/mL);107.01(Max Conc. mM)
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形态:
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Solid
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酸度系数(pKa):
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1.30±0.70(Predicted)
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颜色:
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White to off-white
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288591-93-5性质、用途与生产工艺
Leu-AMS (compound 6),亮氨酸类似物,是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂,IC50 值为 22.34 nM,Leu-AMS 抑制了LRS 的催化活性,但不影响亮氨酸诱导的 mTORC1 活化。Leu-AMS在癌细胞和正常细胞中显示出细胞毒性,并抑制细菌的生长。
Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC
50
value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation.
288591-93-5
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-108900 | 288591-93-5 Leu-AMS | 288591-93-5 | 1mg | 1900元 |
2024/08/19 | HY-108900 | 288591-93-5 Leu-AMS | 288591-93-5 | 5mg | 5900元 |
288591-93-5, 288591-93-5 相关搜索:
- 抑制剂
- 化合物 T11840
- 288591-93-5
- Leu AMS,LeuAMS
- Adenosine, 5'-[[(2S)-2-amino-4-methyl-1-oxopentyl]sulfamate]
- Leu-AMS