3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
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- CAS号:
- 394694-98-5
- 英文名:
- 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide
- 英文别名:
- MB-10;MitoBloCK-10 (MB-10);3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m;3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide;3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide;3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide;Benzoic acid, 3-fluoro-, 2-[(5-nitro-2-thienyl)methylene]hydrazide;Mitochondrial,Protein,Tim44,MitoBloCK10,MitoBloCK 10,MitoBloCK-10,inhibit,Inhibitor,Import
- 中文名:
- 3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
- 中文别名:
- 化合物MITOBLOCK-10;3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼;3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
- CBNumber:
- CB83692152
- 分子式:
- C12H8FN3O3S
- 分子量:
- 293.27
- MOL File:
- 394694-98-5.mol
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3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼化学性质
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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11.21±0.46(Predicted)
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3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼性质、用途与生产工艺
MitoBloCK-10 (MB-10) 是首个减弱 PAM 复合体活性的小分子调节剂。MitoBloCK-10 (MB-10) 可抑制 C 末端结构域的 Tim44 与前体和 Hsp70 结合。
MB-10 (100 μM) is a potential attenuator of protein import into mitochondria.
MB-10 inhibits the import of substrates that use the TIM23 import pathway.
MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria.
Cell Viability Assay
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Cell Line:
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A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.
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Concentration:
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100 μM.
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Incubation Time:
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30 min.
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Result:
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WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil.
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Cell Viability Assay
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Cell Line:
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HeLa cells.
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Concentration:
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0-100 μM.
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Incubation Time:
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24 h.
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Result:
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Inhibited HeLa cells vibility, with an IC
50
of 17.2 μM.
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3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
上下游产品信息
上游原料
下游产品
3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
生产厂家
394694-98-5, 3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼 相关搜索:
- 3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
- 化合物MITOBLOCK-10
- 3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
- 394694-98-5
- 3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide
- Mitochondrial,Protein,Tim44,MitoBloCK10,MitoBloCK 10,MitoBloCK-10,inhibit,Inhibitor,Import
- 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m
- MB-10
- 3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide
- Benzoic acid, 3-fluoro-, 2-[(5-nitro-2-thienyl)methylene]hydrazide
- MitoBloCK-10 (MB-10)
- 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide