网站主页 >> CAS数据库列表 >> (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
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- CAS号:
- 1075723-01-1
- 英文名:
- (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
- 英文别名:
- Fulvene-5;Fulvene5,Fulvene 5;(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole;1H-Indole, 3-(2,4-cyclopentadien-1-ylidene)-2-[3-(2,4-cyclopentadien-1-ylidene)-1,3-dihydro-2H-indol-2-ylidene]-2,3-dihydro-;Fulvene-5 3-(2,4-Cyclopentadien-1-ylidene)-2-[3-(2,4-
cyclopentadien-1-ylidene)-1,3-dihydro-2H-indol-2-
ylidene]-2,3-dihydro-1H-indole
- 中文名:
- (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
- 中文别名:
- 化合物 T11333
- CBNumber:
- CB83889510
- 分子式:
- C26H18N2
- 分子量:
- 358.43
- MOL File:
- 1075723-01-1.mol
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(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole化学性质
(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole性质、用途与生产工艺
Fulvene-5 是一种有效的 NADPH 氧化酶 4 (NOX4) 抑制剂,具有抗氧化特性。Fulvene-5 是一种活性氧 (ROS) 修饰剂和有效的辐射防护剂,并具有抗肿瘤活性。
NADPH oxidase 4 (NOX4); Reactive oxygen species (ROS)
Fulvene-5 (10 µM; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%.
Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells.
Fulvene-5 (120 mg/kg/d; intraperitoneal injection; daily; for 2 weeks; nude mice) treatment potently inhibits hemangioma growth in mice.
Animal Model:
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Nude mice injected with bEnd.3 cells
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Dosage:
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120 mg/kg/d
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Administration:
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Intraperitoneal injection; daily; for 2 weeks
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Result:
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Tumor growth in mice was significantly reduced.
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(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2021/03/30 | S0757 | (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole Fulvene-5 | 1075723-01-1 | 5mg | 3251.43元 |
2021/03/30 | S0757 | (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole Fulvene-5 | 1075723-01-1 | 25mg | 9819.81元 |
(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
生产厂家
1075723-01-1, (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole 相关搜索:
- 化合物 T11333
- 1075723-01-1
- Fulvene5,Fulvene 5
- Fulvene-5 3-(2,4-Cyclopentadien-1-ylidene)-2-[3-(2,4-
cyclopentadien-1-ylidene)-1,3-dihydro-2H-indol-2-
ylidene]-2,3-dihydro-1H-indole
- 1H-Indole, 3-(2,4-cyclopentadien-1-ylidene)-2-[3-(2,4-cyclopentadien-1-ylidene)-1,3-dihydro-2H-indol-2-ylidene]-2,3-dihydro-
- Fulvene-5
- (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole