化合物 T10594
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- CAS号:
- 42494-73-5
- 英文名:
- BPV(PHEN)
- 英文别名:
- BPV(PHEN);K[VO(O2)2C12H8N2] 3H2O;bpV(phen) - CAS 42494-73-5 - Calbiochem;POTASSIUM BISPEROXO(1,10-PHENANTHROLINE)OXOVANADATE (V);Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V) trihydrate
- 中文名:
- 化合物 T10594
- 中文别名:
- 化合物 T10594;BISPEROXO(1,10-菲咯啉)氧钒酸钾(V)三水合物
- CBNumber:
- CB8434973
- 分子式:
- C12H8KN2O5V
- 分子量:
- 350.24
- MOL File:
- 42494-73-5.mol
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化合物 T10594化学性质
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储存条件:
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-20°C
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溶解度:
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H2O: soluble20mg/mL, clear
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形态:
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Yellow solid
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颜色:
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faint yellow to dark yellow
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化合物 T10594性质、用途与生产工艺
bpV(phen)，一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂，对 PTEN，PTP-β 和 PTP-1B 的 IC50 为 38 nM，343 nM 和 920 nM。bpV(phen) 在体外抑制原生动物寄生虫利什曼原虫的增殖。bpV(phen) 强烈诱导大量趋化因子和促炎性细胞因子的分泌，并激活 Th1 型途径 (IL-12，IFNγ)。bpV(phen) 还可以诱导细胞凋亡 (apoptosis)，并具有抗血管生成和抗肿瘤活性。
IC50: 38 nM (PTEN), 343 nM (PTP-β) and 920 nM (PTP-1B)
Parasite
Leishmania
Apoptosis
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells.
After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited.
bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation.
Cell Viability Assay
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Cell Line:
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Hypoxia/reoxygenation (H/R)-injured H9c2 cells
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Concentration:
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5 μM
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Incubation Time:
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24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
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Result:
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Caused a further decrease of cell viability.
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Apoptosis Analysis
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Cell Line:
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Hypoxia/reoxygenation (H/R)-injured H9c2 cells
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Concentration:
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5 μM
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Incubation Time:
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24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
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Result:
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Increased the apoptosis of H/R-injured H9c2 cells.
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Western Blot Analysis
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Cell Line:
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Hypoxia/reoxygenation (H/R)-injured H9c2 cells
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Concentration:
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5 μM
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Incubation Time:
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24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
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Result:
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Showed an increased release of Cytochrome C.
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bpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume.
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Animal Model:
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Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells
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Dosage:
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5 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 38 days
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Result:
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Caused a significant reduction in average tumor volume.
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化合物 T10594
上下游产品信息
上游原料
下游产品
42494-73-5, 化合物 T10594 相关搜索:
- BISPEROXO(1,10-菲咯啉)氧钒酸钾(V)三水合物
- 化合物 T10594
- 42494-73-5
- bpV(phen) - CAS 42494-73-5 - Calbiochem
- Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V) trihydrate
- K[VO(O2)2C12H8N2] 3H2O
- BPV(PHEN)
- POTASSIUM BISPEROXO(1,10-PHENANTHROLINE)OXOVANADATE (V)