TIPEPIDINE HYDROCHLORIDE
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- CAS号:
- 1449686-84-3
- 英文名:
- Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, hydrochloride (1:1)
- 英文别名:
- Tipepidine hydrochloride;Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, hydrochloride (1:1);KcsA,inhibit,Tipepidine hydrochloride,Tipepidine,Potassium Channel,Inhibitor
- 中文名:
- TIPEPIDINE HYDROCHLORIDE
- 中文别名:
- 化合物TIPEPIDINE HYDROCHLORIDE
- CBNumber:
- CB85481619
- 分子式:
- C15H18ClNS2
- 分子量:
- 311.89
- MOL File:
- 1449686-84-3.mol
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TIPEPIDINE HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 41.67 mg/mL (133.60 mM)
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TIPEPIDINE HYDROCHLORIDE性质、用途与生产工艺
Tipepidine hydrochloride 可逆地抑制多巴胺 D2 受体介导的 GIRK 电流 (IDA(GIRK))，从而激活 VTA 多巴胺神经元， 对 IDA(GIRK) 的 IC50 为 7.0 μM。Tipepidine hydrochloride 是一种非麻醉性镇咳药，具有抗抑郁样作用。
IC50: 7.0 μM (dopamine D
2
receptor)
Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats.
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Animal Model:
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Male Wistar rats weighting 150-240 g (5-7 weeks old)
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Dosage:
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10, 20 and 40 mg/kg
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Administration:
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I.p.; 0.5, 5, 23 hours
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Result:
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Decreased the immobility time in the forced swimming test in ACTH-treated rats.
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TIPEPIDINE HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-121685A | TIPEPIDINE HYDROCHLORIDE
Tipepidine hydrochloride | 1449686-84-3 | 10mg | 950元 |
| 2024/01/16 | HY-121685A | TIPEPIDINE HYDROCHLORIDE
Tipepidine hydrochloride | 1449686-84-3 | 5mg | 800元 |
TIPEPIDINE HYDROCHLORIDE
生产厂家
1449686-84-3, TIPEPIDINE HYDROCHLORIDE 相关搜索:
- C15H17NS2ClH
- 化合物TIPEPIDINE HYDROCHLORIDE
- 1449686-84-3
- KcsA,inhibit,Tipepidine hydrochloride,Tipepidine,Potassium Channel,Inhibitor
- Tipepidine hydrochloride
- Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, hydrochloride (1:1)