ZYZ-488
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- CAS号:
- 1470302-79-4
- 英文名:
- ZYZ-488
- 英文别名:
- ZYZ-488;ZYZ 488,ZYZ488;β-D-Glucopyranosiduronic acid, 4-[[4-[(aminoiminomethyl)amino]butoxy]carbonyl]-2,6-dimethoxyphenyl
- 中文名:
- ZYZ-488
- 中文别名:
- 化合物 T13417
- CBNumber:
- CB85821228
- 分子式:
- C20H29N3O11
- 分子量:
- 487.46
- MOL File:
- 1470302-79-4.mol
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ZYZ-488化学性质
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沸点:
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700.6±70.0 °C(Predicted)
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密度:
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1.57±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 200 mg/mL (410.29 mM)
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酸度系数(pKa):
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2.75±0.70(Predicted)
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ZYZ-488性质、用途与生产工艺
ZYZ-488 是一种竞争性凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂，抑制结合蛋白 procaspase-9 和 procaspase-3 的激活。
Apoptotic protease activating factor-1
ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3.
ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases.
ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis.
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Animal Model:
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Male C57BL/6 mice (8-10 weeks old)
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Dosage:
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myocardial infarction + ZYZ-488 (33.9 mg/kg);
myocardial infraction + ZYZ-488 (67.8 mg/kg);
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Administration:
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Intramuscularly; for 3 days
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Result:
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Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3.
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ZYZ-488
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100472 | ZYZ-488 | | 1 mg | 1590元 |
| 2024/04/30 | HY-100472 | ZYZ-488
ZYZ-488 | 1470302-79-4 | 5mg | 3500元 |
1470302-79-4, ZYZ-488 相关搜索:
- C20H29N3O11
- 化合物 T13417
- 1470302-79-4
- ZYZ 488,ZYZ488
- β-D-Glucopyranosiduronic acid, 4-[[4-[(aminoiminomethyl)amino]butoxy]carbonyl]-2,6-dimethoxyphenyl
- ZYZ-488