4-苄氧基苯基异硫氰酸酯
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- CAS号:
- 139667-74-6
- 英文名:
- CGP 52432
- 英文别名:
- P52432;CGP 52432;CGP52432 >=98% (HPLC);CGP 52432;CGP-52432;CGP 52432;(3-((3,4-dichlorobenzyl)amino)propyl)(diethoxymethyl)phosphinic acid;3-([[[(3,4-DICHLOROPHENYL)METHYL]AMINO]PROPYL] DIETHOXYMETHYL)PHOSPHINIC ACID;Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-;Inhibitor,CGP-52432,inhibit,Gamma-aminobutyric acid Receptor,CGP52432,GABA Receptor,γ-Aminobutyric acid Receptor
- 中文名:
- 4-苄氧基苯基异硫氰酸酯
- 中文别名:
- CGP 52432,GABA B拮抗剂;(3-((3,4-二氯苄基)氨基)丙基)(二乙氧基甲基)膦酸;3-[(3,4-二氯苯基)甲基氨基]丙基-(二乙氧基甲基)次膦酸
- CBNumber:
- CB8669551
- 分子式:
- C15H24Cl2NO4P
- 分子量:
- 384.24
- MOL File:
- 139667-74-6.mol
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4-苄氧基苯基异硫氰酸酯化学性质
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沸点:
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544.4±50.0 °C(Predicted)
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密度:
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1.258±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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H2O: soluble1mg/mL, clear (warmed)
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酸度系数(pKa):
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2.26±0.50(Predicted)
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形态:
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powder
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颜色:
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white to beige
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水溶解性:
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Soluble in water (10mM, gentle warming)
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4-苄氧基苯基异硫氰酸酯性质、用途与生产工艺
CGP52432 是一种有效的 GABAB autoreceptor 的选择性拮抗剂，其IC50值为0.085 μM。
| Target | Value |
GABA
B
autoreceptor
(Cell-free assay)
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0.085 μM
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CGP52432 is a GABA
B
receptor antagonist, with an IC
50
of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.
CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
4-苄氧基苯基异硫氰酸酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-103531 | CGP52432 | | 1 mg | 450元 |
| 2024/01/25 | HY-103531 | 4-苄氧基苯基异硫氰酸酯
CGP52432 | 139667-74-6 | 5mg | 990元 |
139667-74-6, 4-苄氧基苯基异硫氰酸酯 相关搜索:
- GABA
- GABA/Glycine receptor
- C15H24Cl2NO4P
- CGP 52432,GABA B拮抗剂
- (3-((3,4-二氯苄基)氨基)丙基)(二乙氧基甲基)膦酸
- 3-[(3,4-二氯苯基)甲基氨基]丙基-(二乙氧基甲基)次膦酸
- 139667-74-6
- Inhibitor,CGP-52432,inhibit,Gamma-aminobutyric acid Receptor,CGP52432,GABA Receptor,γ-Aminobutyric acid Receptor
- (3-((3,4-dichlorobenzyl)amino)propyl)(diethoxymethyl)phosphinic acid
- CGP52432 >=98% (HPLC)
- Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-
- P52432
- CGP 52432;CGP-52432;CGP 52432
- CGP 52432
- 3-([[[(3,4-DICHLOROPHENYL)METHYL]AMINO]PROPYL] DIETHOXYMETHYL)PHOSPHINIC ACID