N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

生物活性靶点体外研究体内研究 N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT 试剂级价格

CAS号:: 51116-00-8

英文名:: N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

英文别名:: DB-cGMP;DBCGMP NA;DIBUTYRYL-CGMP;Bt2cGMP sodium;DIBUTYRYL-CGMP NA;DB-CGMP SODIUM SALT;Dibutyryl-cGMP sodium;N2,2'-O-Dibutyryl cGMP;DIBUTYRYL-CGMP SODIUM SALT;MGBPJXVWDGGLKI-GBIKJYCISA-M

中文名:: N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

中文别名:: 化合物 T11038;二丁酰-CGMP 钠盐

CBNumber:: CB8704951

分子式:: C18H23N5NaO9P

分子量:: 507.37

MOL File:: 51116-00-8.mol

化学性质安全信息用途价格供应商 47

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT化学性质

储存条件:: −20°C

溶解度:: H₂O: 50 mg/mL

形态:: powder

颜色:: off-white

安全信息

WGK Germany:	3

F:	10-21

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT性质、用途与生产工艺

生物活性

Dibutyryl-cGMP sodium (Bt2cGMP sodium) 是细胞可渗透的 cGMP 类似物，可优先激活 cGMP 依赖性蛋白激酶 (PKG)。Dibutyryl-cGMP sodium 抑制 γ 凝血酶刺激的人血小板中 [3H]-花生四烯酸的释放。Dibutyryl-cGMP sodium 可通过激活ATP 敏感的 K+ 通道而具有镇痛作用。

靶点

cGMP-dependent protein kinase (PKG);
ATP-sensitive K ⁺ channels

Dibutyryl-cGMP is able to induce process elongation and branching in astrocytes resulting from a rapid, reversible and concentration-dependent redistribution of glial fibrillary acidic protein (GFAP) and actin filaments without significant change in protein levels.
When cells are co-incubated with Dibutyryl-cGMP (100 μM) stress fibre formation is prevented and cells acquired a stellate morphology in cerebellar astrocytes.
In cells treated with Dibutyryl-cGMP (100 μM, 2 h) the particulate fraction is nearly devoid of RhoA protein. Dibutyryl-cGMP prevents RhoA-membrane association.
Using the scratchwound model, the size of the wound is significantly smaller in cells treated with Dibutyryl-cGMP after the wound indicating that dbcGMP accelerates wound closure.

体内研究

Dibutyryl-cGMP (50-200 μg/paw; subcutaneous injection; male Wistar rats) treatment antagonizes the hyperalgesic effect of PGE2 in a dose-dependent manner. Maximal antinociceptive effect of DbcGMP is at 1 h after administration and last for plus 2 h.

Animal Model:	Male Wistar rats (180- 250 g) injection with Prostaglandin E2 (PGE2)
Dosage:	50 μg/paw, 75 μg/paw, 100 μg/paw and 200 μg/paw
Administration:	Subcutaneous injection
Result:	Antagonized the hyperalgesic effect of PGE2 (2 μg/paw), in a dose-dependent manner.

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT 上下游产品信息

上游原料

下游产品

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/01/25	HY-130354	Dibutyryl-cGMP sodium		1 mg	1590元
2024/01/25	HY-130354	N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Dibutyryl-cGMP sodium	51116-00-8	5mg	3500元

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT 生产厂家

全球有 47家供应商 N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海阿拉丁生化科技股份有限公司	400-6206333 18521732826	market@aladdin-e.com	中国	25015	65
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9709	58
上海宏叶生物科技有限公司	400-9205774	sales@glpbio.cn	中国	6870	58
BOC Sciences	+16314854226	inquiry@bocsci.com	美国	19743	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
BOC Sciences	16314854226	inquiry@bocsci.com	美国	9713	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
MedBio脉铂医药	021-69568360 18916172912	order@med-bio.cn	中国	8141	58
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing@energy-chemical.com	中国	44941	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29834	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24131	58
Aladdin Scientific Corporation	+1-833-552-7181	sales@aladdinsci.com	美国	57511	58
杭州摩库生物医药科技有限公司	+86-057181025280; +8617767106207	sales@molcore.com	中国	49739	58

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Serine/Threonine Kinase Activators
Protein Kinase G (PKG)
G Proteins and Cyclic Nucleotides
Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology
Cyclic Nucleotide Metabolism
Nucleotide Analogs
Nucleosides, Nucleotides, Oligonucleotides
Biochemicals and Reagents
生化试剂
Cell Signaling and Neuroscience
Cell Biology
BioChemical
Biochemicals and Reagents
Cyclic Nucleotides and Analogs
Cyclic Nucleotide Metabolism
G Proteins and Cyclic Nucleotides
Nucleosides, Nucleotides, Oligonucleotides
Nucleotide Analogs
C18H24N5NaO9P
C18H23N5NaO9P2H2O
C18H23N5NaO9P
二丁酰-CGMP 钠盐
化合物 T11038
51116-00-8
N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSP...
DibutyrylcGMP sodium,Dibutyryl cGMP sodium
DB-cGMP
Dibutyryl-cGMP sodium
Bt2cGMP sodium
Guanosine 3,5-cyclic Monophosphate, N2,2-O-Dibutyryl-, Sodium Salt - CAS 51116-00-8 - Calbiochem
MGBPJXVWDGGLKI-GBIKJYCISA-M
N2 2'-O-DIBUTYRYLGUANOSINE-3' 5'-CYCLO-&
N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPH
Guanosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt
N2,2'-O-dibutyrylguanosine-3',5'-cyclo-phos. so-sa. dihyd.
N2,2-O-Dibutyrylguanosine 3,5-cyclic monophosphate sodium salt dihydrate
Guanosine, 3,5-cyclic Monophosphate, N2,2-O-Dibutyryl-,
DIBUTYRYL-CGMP SODIUM SALT
DIBUTYRYL-CGMP NA
DIBUTYRYL-CGMP
DB-CGMP SODIUM SALT
DBCGMP NA
GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, N2,2'-O-DIBUTYRYL-, SODIUM SALT
N2-2''-O-Dibutyrylguanosine-3'',5''-cyclic monophosphoric acid
N2,2'-O-DIBUTYRYLGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
n2,2’-o-dibutyrylguanosine-3’,5’-cyclicmonophosphate(dbcgmp),sodiumsalt
Dibutyryl-Cyclic GMP (sodium salt)
N2,2'-O-Dibutyryl cGMP
N,2'-O-Dibutyrylguanosine 3',5'-phosphoric acid
N2,2μ-O-Dibutyrylguanosine 3μ,5μ-cyclic monophosphate dihydrate sodium salt
N2,2μ-O-Dibutyrylguanosine 3μ,5μ-cyclic monophosphate hydrate sodium salt
dibutyryl cyclic 3',5'-guanosine monophosphate, sodium