鼠尾草苦内脂又叫鼠尾草酚，是一种存在于迷迭香和丹参等植物中的天然二萜化合物，具有很强的降血脂、抗氧化、抗肿瘤、抗病毒和抗炎特性，已广泛用于保健、食品、天然色素、化妆品等领域，据报道，鼠尾草苦内脂可以通过抑制NF-κB通路而具有抗肿瘤的作用，也可以诱导T细胞白血病、淋巴瘤细胞凋亡并降低血清中的IL-6和TNF-α水平。
RSK2
~5.5 μM (IC 50 )
Nrf2
It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.
Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.