新霉素标液
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- CAS号:
- 119-04-0
- 英文名:
- NEOMYCIN B
- 英文别名:
- actilin;actiline;framygen;Framidal;Framycin;enterfram;Francetin;Fraquinol;framycetin;NEOMYCIN B
- 中文名:
- 新霉素标液
- 中文别名:
- 新霉素B;新霉素溶液;新霉素标液;新霉素B六乙酸酯;化合物 T15348;硫酸弗兰西汀(新霉素B);新霉素溶液 T1850 上海瑞楚;新霉素溶液 T1779 上海瑞楚;新生霉素溶液 T1481 上海瑞楚;新生霉素溶液 T1462 上海瑞楚
- CBNumber:
- CB8761428
- 分子式:
- C23H46N6O13
- 分子量:
- 614.64
- MOL File:
- 119-04-0.mol
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新霉素标液化学性质
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熔点:
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>194°C (dec.)
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沸点:
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658.4°C (rough estimate)
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密度:
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1.3548 (rough estimate)
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折射率:
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1.6000 (estimate)
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储存条件:
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2-8°C
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溶解度:
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Aqueous Acid (Slightly), Water (Slightly)
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形态:
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liquid
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酸度系数(pKa):
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12.93±0.70(Predicted)
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颜色:
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clear
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Merck:
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13,6482
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稳定性:
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Hygroscopic
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新霉素标液性质、用途与生产工艺
Framycetin (Neomycin B) 是一种氨基糖苷类抗生素，是一种有效的 RNase P 裂解活性抑制剂，Ki 为 35 μM。Framycetin 竞争 RNase P RNA 中特定的二价金属离子结合位点。Framycetin 抑制锤头状核酶 (hammerhead ribozyme)，Ki 值为 13.5 μM。Framycetin 是 5″-azido neomycin B 前体，与 miR-525 中的 Drosha 位点结合，可用于肝性脑病和肠致病性大肠杆菌感染。
Ki: 35 μM (RNase P cleavage activity) and 13.5 μM (hammerhead ribozyme)
The inhibition of RNase P RNA cleavage by Framycetin (Neomycin B; Fradiomycin B) is sensitive to pH and an increase in pH suppresses the inhibition in other systems.
Framycetin targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line.
Framycetin binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function.
Framycetin induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region.
新霉素标液
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-17624 | Framycetin | | 25 mg (16.27 mM * 2.5 mL in 0.9% NaCl) | 500元 |
| 2024/01/25 | HY-17624 | Framycetin | | 50 mg (16.27 mM * 5 mL in 0.9% NaCl) | 800元 |
新霉素标液
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119-04-0, 新霉素标液 相关搜索:
- Interferes with Protein SynthesisSpectrum of Activity
- Genetic Marker SelectionAntibiotics
- Chemical Structure Class
- Antineoplastic and Immunosuppressive AntibioticsAntibiotics
- Antibiotics N-SAntibiotics
- Antibiotics by Application
- Antibiotics A to
- Antibiotics
- Antibacterial
- AminoglycosidesAntibiotics
- NA - NIMore...Close...
- L - ZAlphabetic
- N
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- 原料药 API
- Antibiotics N-S
- Antibiotics
- Antibiotics A to Z
- BioChemical
- 1190-04-0
- 新霉素溶液 T1850 上海瑞楚
- 新霉素溶液 T1779 上海瑞楚
- 新生霉素溶液 T1481 上海瑞楚
- 新生霉素溶液 T1462 上海瑞楚
- 化合物 T15348
- 新霉素B六乙酸酯
- 新霉素标液
- 硫酸弗兰西汀(新霉素B)
- 新霉素B
- 新霉素溶液
- 119-04-0
- Neomycin B Hexaacetate
- FRADIOMYCIN B; NEOMYCIN B
- NEOMYCIN B USP/EP/BP
- D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
- Leo Red Dry Cow
- Fraquinol
- Francetin
- Framycin
- Framidal
- Dekamycin III
- Antibiotique EF 185
- Antibiotic 10676
- Neomycin solution
- (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
- (2R,3S,4R,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-6-(aminomethyl)-3-azanyl-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-bis(azanyl)-3-hydroxy-cyclohexyl]oxy-5-azanyl-oxane-3,4-diol
- 4-O-(2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-2-deoxy-D-streptamine
- soframycine
- soframycin
- framygen
- framycetin
- enterfram
- antibiotique
- actiline
- actilin
- NEOMYCIN B
- NEOMYCIN STANDARD
- D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-