NF 157
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- CAS号:
- 104869-26-3
- 英文名:
- NF 157
- 英文别名:
- NF 157;8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt
- 中文名:
- NF 157
- 中文别名:
- 化合物 T16291
- CBNumber:
- CB8842721
- 分子式:
- C49H28F2N6O23S6.6Na
- 分子量:
- 1437.11
- MOL File:
- 104869-26-3.mol
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NF 157化学性质
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储存条件:
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Desiccate at RT
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Powder
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水溶解性:
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Soluble to 50 mM in water
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稳定性:
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Hygroscopic
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NF 157性质、用途与生产工艺
NF157 是一种高度选择性的 P2Y11 拮抗剂，pKi 为 7.35。对 P2Y11 (Ki=44.3 nM)，P2Y1 (Ki=187 µM)，P2Y2 (Ki=28.9 µM) 的 IC50 分别为 463 nM，1811 µM， 170 µM。NF157 能显着降低金属蛋白酶 (MMP)-3，MMP-13 的表达，可用于骨关节炎的研究。
pKi: 7.35 (P2Y11)
IC50: 463 nM (P2Y11), 1811 µM (P2Y1), 170 µM (P2Y2)
Ki: 44.3 nM (P2Y11), 187 µM (P2Y1), 28.9 µM (P2Y2)
NF157 displays selectivity for P2Y11 over P2Y1 (>650-fold), P2Y2 (>650-fold), P2X2 (3-fold), P2X3 (8-fold), P2X4 (>22-fold), and P2X7 (>67-fold) but no selectivity over P2X1.
NF157 (30 and 60 µM; 24 hours) causes a significant reduction in degradation of type II collagen in a dose-dependent manner. 60 µM NF157 nearly completely rescues type II collagen from degradation induced by TNF-α (10 ng/mL).
NF157 (30 and 60 µM; 24 hours) almost fully restores nuclear translocation of p65 triggered by TNF-α (10 ng/mL) and significantly reduces the luciferase activity of NF-κB.
Western Blot Analysis
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Cell Line:
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SW1353 cells
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Concentration:
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30 and 60 µM
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Incubation Time:
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24 hours
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Result:
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Ameliorated TNF-α-induced degradation of type II collagen.
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Western Blot Analysis
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Cell Line:
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SW1353 cells
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Concentration:
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30 and 60 µM
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Incubation Time:
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24 hours
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Result:
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Reduced TNF-α-induced activation of NF-κB.
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NF 157
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-108672 | NF157 | | 1 mg | 2800元 |
104869-26-3, NF 157 相关搜索:
- C49H28F2N6Na6O23S6
- 化合物 T16291
- 104869-26-3
- 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt
- NF 157