SURAMIN
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- CAS号:
- 145-63-1
- 英文名:
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- 英文别名:
- Naganil;Fourneau;Suramine;Naphuride;Farma 939;Aids000067;Aids-000067;129-46-4(Hexasodium salt);8,8-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid;8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
- 中文名:
- SURAMIN
- 中文别名:
- 苏拦明;苏拉灭;舒拉明
- CBNumber:
- CB8906847
- 分子式:
- C51H40N6O23S6
- 分子量:
- 1297.28
- MOL File:
- 145-63-1.mol
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SURAMIN化学性质
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熔点:
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128 °C(Solv: ethyl ether (60-29-7))
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密度:
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1.2629 (rough estimate)
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折射率:
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1.7770 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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-1.35±0.40(Predicted)
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颜色:
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Pinkish-white, hygroscopic powder
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EPA化学物质信息:
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Suramin (145-63-1)
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SURAMIN性质、用途与生产工艺
Suramin 是一种可逆的，竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。Suramin 是有效的 sirtuins 抑制剂：SirT1 (IC50=297 nM)，SirT2 (IC50=1.15 μM)，SirT5 (IC50=22 μM)。Suramin 是竞争性逆转录酶抑制剂 (DNA topoisomerase II: IC50=5 μM)。Suramin 是一种有效的 SARS-CoV-2 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。Suramin 有效抑制 IP5K，并且是抗寄生虫 (antiparasitic)，抗肿瘤和抗血管生成剂。
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SIRT1
297 nM (IC
50
)
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SIRT2
1.15 μM (IC
50
)
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SIRT5
22 μM (IC
50
)
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Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells.
Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells.
Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2.
The IC
50
values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively.
Suramin blocks viral replication in Vero E6 cells.
Cell Proliferation Assay
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Cell Line:
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HO-8910 PM ovarian and Hela cervical cancer cells
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Concentration:
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50, 100, 200, 300, 400, 500 and 600 μg/mL
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Incubation Time:
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For 24, 48, 72 and 96 hours
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Result:
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Inhibited cells proliferation in a dose-dependent and time-dependent manner.
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Apoptosis Analysis
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Cell Line:
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HeLa cells
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Concentration:
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300 μg/mL
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Incubation Time:
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For 48 hours
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Result:
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Induced cells apoptosis.
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Western Blot Analysis
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Cell Line:
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PA-SMCs cells
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Concentration:
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1 mg/mL
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Incubation Time:
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For 1 hours
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Result:
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Significantly suppressed the phosphorylated ERK1/2.
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Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure.
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Animal Model:
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Adult male Wistar rats (200-225 g)
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Dosage:
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10 mg/kg
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Administration:
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IV; twice weekly for 3 weeks
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Result:
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Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.
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类别
有毒物品
毒性分级
中毒
急性毒性
静脉-小鼠 LD50: 620 毫克/公斤
可燃性危险特性
可燃; 燃烧产生有毒氮氧化物和硫氧化物烟雾
储运特性
通风低温干燥
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
SURAMIN
上下游产品信息
上游原料
下游产品
145-63-1, SURAMIN 相关搜索:
- C51H40N6O23S6
- 苏拦明
- 苏拉灭
- 舒拉明
- 145-63-1
- 8,8-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- 8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-Methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonic acid)
- 1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[iMino-3,1-phenylenecarbonyliMino(4-Methyl-3,1-phenylene)carbonyliMino]]bis-
- Naganil
- Aids-000067
- Aids000067
- 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
- 129-46-4(Hexasodium salt)
- Suramine
- Naphuride
- Fourneau
- Farma 939
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid