利马扎封
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- CAS号:
- 99593-25-6
- 英文名:
- Rilmazafone
- 英文别名:
- Rhythmy;450191-S;Rilmazafone;2',5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone;N,N-Dimethyl-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-5-(aminoacetylaminomethyl)-1H-1,2,4-triazole-3-carboxamide;5-((2-Aminoacetamido)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide;5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide;5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide;5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-earboxamide;1H-1,2,4-Triazole-3-carboxamide, 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-
- 中文名:
- 利马扎封
- 中文别名:
- 利马扎封;利马扎酮;化合物 T13871;5-((2-氨基乙酰胺基)甲基)-1-(4-氯-2-(2-氯苯甲酰基)苯基)-N,N-二甲基-1H-1,2,4-三唑-3-甲酰胺;5-[[(氨基乙酰基)氨基]甲基]-1-[4-氯-2-(2-氯苯甲酰基)苯基]-N,N-二甲基-1H.1,2,4-三唑-3-甲酰胺
- CBNumber:
- CB8969664
- 分子式:
- C21H20Cl2N6O3
- 分子量:
- 475.33
- MOL File:
- 99593-25-6.mol
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利马扎封化学性质
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密度:
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1.45±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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13.13±0.46(Predicted)
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InChI:
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InChI=1S/C21H20Cl2N6O3/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23/h3-9H,10-11,24H2,1-2H3,(H,25,30)
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InChIKey:
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KYHFRCPLIGODFH-UHFFFAOYSA-N
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SMILES:
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N1(C2=CC=C(Cl)C=C2C(=O)C2=CC=CC=C2Cl)C(CNC(CN)=O)=NC(C(N(C)C)=O)=N1
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利马扎封性质、用途与生产工艺
Rilmazafone 是一种苯二氮卓类 ω 配体,具有镇静和催眠作用。
化学性质
单盐酸利马扎封(Rilmazafone Monohydrochloride):C2lH20C12N6O3?HCl2H2O。从95%乙醇得固体,熔点107℃。急性毒性LD
50。小鼠(mg/kg):>1500口服。
用途
其作用类似苯并二氮杂卓类药物,通过增强中枢神经系统中γ-氨基丁酸所传递的抑制机理而起作用。用于失眠及麻醉前给药。
生产方法
下列化合物和二甲胺反应后,再和酞酰甘氨酰甘氨酰氯反应,然后在乙酸作用下环合,最后胼还原、盐酸酸化得单盐酸利马扎封。
利马扎封
上下游产品信息
上游原料
下游产品
99593-25-6, 利马扎封 相关搜索:
- 99593-25-6
- 中枢神经系统用药
- 镇静催眠药
- 药物
- C21H20Cl2N6O3
- 99593-29-6
- 利马扎酮
- 5-((2-氨基乙酰胺基)甲基)-1-(4-氯-2-(2-氯苯甲酰基)苯基)-N,N-二甲基-1H-1,2,4-三唑-3-甲酰胺
- 化合物 T13871
- 利马扎封
- 5-[[(氨基乙酰基)氨基]甲基]-1-[4-氯-2-(2-氯苯甲酰基)苯基]-N,N-二甲基-1H.1,2,4-三唑-3-甲酰胺
- 99593-25-6
- 5-((2-Aminoacetamido)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide
- Rhythmy
- 1H-1,2,4-Triazole-3-carboxamide, 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-
- 2',5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone
- N,N-Dimethyl-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-5-(aminoacetylaminomethyl)-1H-1,2,4-triazole-3-carboxamide
- 5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide
- 5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-earboxamide
- 450191-S
- 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide
- Rilmazafone