网站主页 >> CAS数据库列表 >> 4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
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- CAS号:
- 2376137-05-0
- 英文名:
- MS21
- 英文别名:
- MS21;4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide;4-amino-N-[(1S)-1-(4-chlorophenyl)-3-[4-(10-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}decanoyl)piperazin-1-yl]propyl]-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperidine-4-carboxamide
- 中文名:
- 4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
- 中文别名:
- 4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-;4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
- CBNumber:
- CB89817454
- 分子式:
- C58H79ClN12O6S
- 分子量:
- 1107.85
- MOL File:
- 2376137-05-0.mol
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4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺化学性质
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密度:
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1.267±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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13.93±0.50(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺性质、用途与生产工艺
4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺 是一种新型的 AKT 降解物，通过选择性地抑制 PI3K/PTEN 途径突变癌症的生长。
4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
上下游产品信息
上游原料
下游产品
4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
生产厂家
2376137-05-0, 4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺 相关搜索:
- C58H79ClN12O6S
- 4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-
- 4-氨基-N-((S)-1-(4-氯苯基)-3-(4-(11-(((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基甲酰基)吡咯烷-1-基)-3,3-二甲基-1-氧代丁烷-2-基)氨基)-11-氧代十一烷酰基)哌嗪-1-基)丙基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-甲酰胺
- 2376137-05-0
- 4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
- 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-[4-(10-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}decanoyl)piperazin-1-yl]propyl]-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperidine-4-carboxamide
- MS21