反-4-羧基-5-辛基-3-甲基-丁内酯
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- CAS号:
- 191282-48-1
- 英文名:
- C75
- 英文别名:
- C75;C75 (trans);C75 (racemic);C 75 trC-75 trans-racemic;4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID;TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID;(2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID;trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid;trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid;(2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
- 中文名:
- 反-4-羧基-5-辛基-3-甲基-丁内酯
- 中文别名:
- C75反式;C75 (RACEMIC),抑制剂;反-4-羧基-5-辛基-3-甲基-丁内酯;脂肪酸合成酶FASN有效抑制剂(C75 TRANS);反式-4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸;反式-四氢-4-亚甲基-2-辛基-5-氧代-3-呋喃羧酸
- CBNumber:
- CB9114164
- 分子式:
- C14H22O4
- 分子量:
- 254.32
- MOL File:
- 191282-48-1.mol
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反-4-羧基-5-辛基-3-甲基-丁内酯化学性质
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沸点:
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432.1±45.0 °C(Predicted)
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密度:
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1.08±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 18 mg/mL
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形态:
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solid
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酸度系数(pKa):
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3.08±0.40(Predicted)
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颜色:
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off-white
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反-4-羧基-5-辛基-3-甲基-丁内酯性质、用途与生产工艺
C75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具。
| Target | Value |
FASN
(clonogenic assay)
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35 μM
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FASN
(spheroid growth assay)
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50 μM
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trans-C75 ((±)-C75) inhibits PC3 cell growht with an IC
50
of 35 μM at 24 h.
trans-C75 ((±)-C75)(10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC
50
of 50 μM.
trans-C75 ((±)-C75) inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption.
trans-C75 ((±)-C75) inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity.
C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.
反-4-羧基-5-辛基-3-甲基-丁内酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S8915 | 反-4-羧基-5-辛基-3-甲基-丁内酯
C75 trans | 191282-48-1 | 10mM(1mL in DMSO) | 1040.13元 |
| 2024/01/16 | S8915 | 反-4-羧基-5-辛基-3-甲基-丁内酯
C75 trans | 191282-48-1 | 5mg | 1358.13元 |
反-4-羧基-5-辛基-3-甲基-丁内酯
生产厂家
191282-48-1, 反-4-羧基-5-辛基-3-甲基-丁内酯 相关搜索:
- pharmacetical
- 药靶配体
- 试剂盒-细胞分析试剂盒
- 抑制剂
- 细胞生物学试剂
- C75 (RACEMIC),抑制剂
- 反式-4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸
- C75反式
- 脂肪酸合成酶FASN有效抑制剂(C75 TRANS)
- 反-4-羧基-5-辛基-3-甲基-丁内酯
- 反式-四氢-4-亚甲基-2-辛基-5-氧代-3-呋喃羧酸
- 191282-48-1
- (2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
- trans-C-75,Fatty Acid Synthase (FASN),Inhibitor,inhibit,trans C75,trans-C75,transC75
- 3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2R,3S)-rel-
- C 75 trC-75 trans-racemic
- (2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
- C75 (racemic)
- trans-C 75 (trans-4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid)
- 4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID
- C75 (trans)
- trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
- trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid
- (2R,3S)-rel-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid
- (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicacid
- (2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID
- C75
- TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID