氯德拉苯
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- CAS号:
- 111149-90-7
- 英文名:
- Declaben
- 英文别名:
- SC-39026;Declaben;Lodelaben;Lodelabenum;Lodelaben (SC-39026);Lodelabenum [inn-latin];Benzoic acid, 2-chloro-4-(1-hydroxyoctadecyl)-
- 中文名:
- 氯德拉苯
- 中文别名:
- 氯德拉苯;化合物 T11865;LODELABEN (SC-39026)
- CBNumber:
- CB91178428
- 分子式:
- C25H41ClO3
- 分子量:
- 425.04
- MOL File:
- 111149-90-7.mol
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氯德拉苯化学性质
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沸点:
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539.8±40.0 °C(Predicted)
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密度:
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1.038±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.09±0.25(Predicted)
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氯德拉苯性质、用途与生产工艺
Lodelaben 是一种人类嗜中性粒细胞弹性蛋白酶抑制剂,其 IC50 和 Ki 值分别 0.5 和 1.5 μM。
IC50: 0.5 μM (elastase)
Ki: 1.5 μM (elastase)
Lodelaben is a human neutrophil elastase inhibitor with an IC
50
and K
i
of 0.5 and 1.5 μM, respectively. Results indicate that the inhibition of human neutrophil elastase (HNE) by Lodelaben is non-competetive. Lodelaben is not inhibitory at 10 μM with the synthetic substrates or at 5 μM vith Azocoll. Pseudomonas aeruginosa elastase, a metallo-protease is not inhibited by Lodelaben. Cathepsin G activity, however, is inhibited by Lodelaben, with an IC
50
of approximately 2.5 μM, with Azocoll as substrate.
The mean pulmonary artery pressures of the saline/vehicle and saline/Lodelaben groups are similar, 16.4±1.1 and 17.4±0.9 mm Hg, respectively. Although, mean pulmonary artery pressure in the monocrotaline/vehicle group is 27.5±0.8 mm Hg, treatment of monocrotaline rats with Lodelaben results in significantly lower values (21.00±1.6 mm Hg, p<0.05). Saline/vehicle and saline/Lodelaben rats have only a small percentage of arteries muscularized at the alveolar wall level (1.9±1.4 and 0.4±0.4%, respectively). Treatment of monocrotaline-injected rats with Lodelaben results in a decreased percentage of alveolar wall arteries muscularized (10.0±3.6%).
氯德拉苯
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-100240 | Lodelaben | | 1 mg | 9800元 |
2023/03/20 | HY-100240 | 氯德拉苯 Lodelaben | 111149-90-7 | 5mg | 36000元 |
111149-90-7, 氯德拉苯 相关搜索:
- 抑制剂
- C25H41ClO3
- LODELABEN (SC-39026)
- 化合物 T11865
- 氯德拉苯
- 111149-90-7
- Lodelaben (SC-39026)
- SC-39026
- Lodelabenum [inn-latin]
- Lodelabenum
- Benzoic acid, 2-chloro-4-(1-hydroxyoctadecyl)-
- Lodelaben
- Declaben