RP-54745
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- CAS号:
- 135330-08-4
- 英文名:
- RP 54745
- 英文别名:
- RP 54745;inhibit,RP-54745,RP 54745,Inhibitor,RP54745,Interleukin Related;4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one;3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
- 中文名:
- RP-54745
- 中文别名:
- 化合物RP-54745;4-氯-5-(1-甲基-3,4-二氢异喹啉-2(1H)-基)-3H-1,2-二硫醇-3-酮
- CBNumber:
- CB91338303
- 分子式:
- C13H12ClNOS2
- 分子量:
- 297.82
- MOL File:
- 135330-08-4.mol
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RP-54745化学性质
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沸点:
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411.4±55.0 °C(Predicted)
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密度:
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1.46±0.1 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO : 62.5 mg/mL (209.86 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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-2.57±0.40(Predicted)
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RP-54745性质、用途与生产工艺
RP-54745 是一种潜在的治风湿化合物，能够抑制噬细胞刺激和的白介素-1 (interleukin-1) 的产生。
RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages.
RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745.
RP-54745
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101716 | RP-54745
RP-54745 | 135330-08-4 | 1mg | 1000元 |
| 2024/01/25 | HY-101716 | RP-54745
RP-54745 | 135330-08-4 | 5mg | 2000元 |
135330-08-4, RP-54745 相关搜索:
- 4-氯-5-(1-甲基-3,4-二氢异喹啉-2(1H)-基)-3H-1,2-二硫醇-3-酮
- 化合物RP-54745
- 135330-08-4
- inhibit,RP-54745,RP 54745,Inhibitor,RP54745,Interleukin Related
- 3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
- 4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one
- RP 54745