MS-444
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- CAS号:
- 150045-18-4
- 英文名:
- 5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
- 英文别名:
- MS-444;BE-34776;MS 444,MS444;5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone;Naphtho[2,3-c]furan-4(9H)-one, 5,8-dihydroxy-3-methyl-
- 中文名:
- MS-444
- 中文别名:
- 抗生素 MS-444;化合物 T16145
- CBNumber:
- CB91339067
- 分子式:
- C13H10O4
- 分子量:
- 230.22
- MOL File:
- 150045-18-4.mol
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MS-444化学性质
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沸点:
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448.7±45.0 °C(Predicted)
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密度:
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1.452±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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8.14±0.20(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to brown
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MS-444性质、用途与生产工艺
MS-444 是平滑肌肌球蛋白轻链激酶 (MLCK) 的抑制剂,IC50 值为 10 μM。
MS-444 is a small molecule RNA-binding protein HuR (ELAVL1) inhibitor. Colorectal cancer (CRC) cells that display HuR overexpression are treated with MS-444 (1-100 μM) for 48 hr with IC
50
s of 10.98±1.76 μM, 12.84±2.10 μM, 5.60±0.90 μM, 14.21±2.11 μM, and 10.98±1.24 μM for HCT116, HCA-7, RKO, HT-29, and SW480 cells, respectively. Growth inhibition is observed in all CRC lines with IC
50
values ranging from 5.60 μM to 14.21 μM with observable effects seen at 10 μM MS-444. Contrasting effects are observed using non-transformed small intestinal (RIE-1 (IC
50
=40.70±3.53 μM)) and colonic (YAMC (IC
50
=28.16±3.23 μM)) epithelial cells. Both cell types display properties of normal intestinal epithelial cells and are proficient in 3′UTR AU-rich elements (ARE)-mRNA decay. Both non-transformed cell lines are ~3- to 4-fold less responsive to MS-444-mediated growth inhibition, with IC
50
values of 40.70 μM and 28.16 μM (
P
<0.05).
To test the effects of MS-444 on CRC cell growth in vivo, mice bearing HCT116 cell xenografts receive IP injections of MS-444 (25 mg/kg bw) or vehicle every 48 hr. Over the experiment course, mice do not display any adverse effects and maintained similar weights. Anti-tumor effects of MS-444 are observed with approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 show a marked 2- to 3-fold decrease in microvessel density (MVD), indicating the anti-angiogenic potential of MS-444.
MS-444
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100685 | MS-444 | | 1 mg | 3000元 |
2024/08/19 | HY-100685 | MS-444 MS-444 | 150045-18-4 | 5mg | 7500元 |
150045-18-4, MS-444 相关搜索:
- 抗生素 MS-444
- 化合物 T16145
- 150045-18-4
- MS 444,MS444
- Naphtho[2,3-c]furan-4(9H)-one, 5,8-dihydroxy-3-methyl-
- BE-34776
- MS-444
- 5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone