107889-32-7
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- CAS号:
- 107889-32-7
- 英文名:
- LY 178002
- 英文别名:
- LY 178002;5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]thiazolidin-4-one;4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
- 中文名:
- 107889-32-7
- 中文别名:
- 化合物 T15825
- CBNumber:
- CB91374387
- 分子式:
- C18H25NO2S
- 分子量:
- 319.46
- MOL File:
- 107889-32-7.mol
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107889-32-7化学性质
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沸点:
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489.9±45.0 °C(Predicted)
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密度:
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1.139±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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11.15±0.50(Predicted)
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107889-32-7性质、用途与生产工艺
LY 178002 是一种有效的 5-lipoxygenase (5-LPO) ，phospholipase A2 抑制剂，对 5-lipoxygenase 的 IC50 值为 0.6 μM，能够抑制人多形核白细胞产生 LTB4，同时可相对较弱地抑制 cyclooxygenase 的活性。
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5-LPO
0.6 μM (IC
50
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PLA2
6.3 μM (IC
50
)
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FCO
4.2 μM (IC
50
)
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Cyclooxygenase
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LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC
50
s of 0.1, 6.3 and 4.2 μM .
LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%.
107889-32-7
上下游产品信息
上游原料
下游产品
107889-32-7, 107889-32-7 相关搜索:
- 抑制剂
- 化合物 T15825
- 107889-32-7
- 4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
- 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]thiazolidin-4-one
- LY 178002