SAG
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- CAS号:
- 912545-86-9
- 英文名:
- SAG
- 英文别名:
- SAG;SAG.HCI;CS-1655;SAG free base;SAG (Smo agonist);Smoothened Agonist;SAG.HCl(free base);SAG(Smoothened Agonist);Smoothened Agonist (SAG);SAG (Smo agonist) free base
- 中文名:
- SAG
- 中文别名:
- SAG 二盐酸盐;SMO RECEPTOR激动剂(SAG);3-氯-N-[反式-4-(甲基氨基)环己基]-N-[[3-(4-吡啶基)苯基]甲基]-苯并[B]噻吩-2-甲酰胺
- CBNumber:
- CB91565561
- 分子式:
- C28H28ClN3OS
- 分子量:
- 490.06
- MOL File:
- 912545-86-9.mol
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SAG化学性质
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沸点:
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688.6±55.0 °C(Predicted)
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密度:
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1.30±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
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酸度系数(pKa):
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10?+-.0.40(Predicted)
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形态:
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lyophilized solid
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颜色:
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white to beige
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敏感性:
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Light Sensitive
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稳定性:
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Light Sensitive
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SAG性质、用途与生产工艺
SAG 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。SAG 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。
SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC
50
of 3 nM and then inhibits expression at higher concentrations.
SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, yielding an apparent dissociation constant (K
d
) of 59 nM for the SAG/Smo complex.
SAG (100 nM) inhibits the inhibitory effect of ShhN-induced pathway activation by Robotnikinin.
SAG (250 nM; 48 h) significantly increases SMO mRNA and protein expression in MDAMB231 cells.
SAG (250 nM; 24 and 48 h) increases CAXII mRNA expression in MDAMB231 cells at 24h in normoxic and hypoxic conditions in MDAMB231 cells.
SAG (250 nM; 24 h) increases MDAMB231 cells migration.
SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice.
SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice.
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Animal Model:
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Pregnant C57BL/6J mice
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Dosage:
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15, 17, 20 mg/kg
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Administration:
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A single i.p.
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Result:
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Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
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SAG
上下游产品信息
上游原料
下游产品
SAG
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912545-86-9, SAG 相关搜索:
- Heterocycles
- Heterocyclic Compounds
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- 合成有机化合物配体
- 试剂盒-Elisa试剂盒
- 抑制剂
- 细胞生物学试剂
- 小分子抑制剂
- 小分子抑制剂，天然产物
- C28H28ClN3OS
- 5054-47-5
- SAG 二盐酸盐
- SMO RECEPTOR激动剂(SAG)
- 3-氯-N-[反式-4-(甲基氨基)环己基]-N-[[3-(4-吡啶基)苯基]甲基]-苯并[B]噻吩-2-甲酰胺
- 912545-86-9
- (2R,3S,5R)-2-((((S)-(((2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- 3-Chloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
- SAG.HCl(free base)
- SAG (Smo agonist) free base
- Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-
- SAG; SAG FREE BASE; SAG (SMO AGONIST); SAG (CYCLOPAMINE ANTAGONIST);
- SAG free base
- Smoothened Agonist
- 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide
- CS-1655
- Smoothened Agonist (SAG) free base
- Smoothened Agonist (SAG)
- SAG(Smoothened Agonist)
- SAG.HCI
- Smoothened Agonist (SAG) HCl
- 3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
- SAG (Smo agonist)
- SAG (cyclopamine antagonist)
- 3-Chloro-N-[trans-4-(MethylaMino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]Methyl]-
- SAG
- 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- benzo[b]thiophene-2-carboxamide