网站主页 >> CAS数据库列表 >> 6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
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- CAS号:
- 212391-63-4
- 英文名:
- PD 166285
- 英文别名:
- PD 166285;PD 166285 dihydrochloride;PD0166285 dihydrochloride;PD 166285 ISO 9001:2015 REACH;PD 166285 - CAS 212391-63-4 - Calbiochem;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride;6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
- 中文名:
- 6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
- 中文别名:
- PD 166285 双盐酸盐;6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
- CBNumber:
- CB91873310
- 分子式:
- C26H29Cl4N5O2
- 分子量:
- 585.37
- MOL File:
- 212391-63-4.mol
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6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐化学性质
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熔点:
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239-242?C
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储存条件:
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Desiccate at RT
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溶解度:
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DMSO, Methanol
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形态:
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Pale yellow solid
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颜色:
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Yellow
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稳定性:
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Hygroscopic
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6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐性质、用途与生产工艺
PD0166285 dihydrochloride是 P-gp 的一个底物,是 WEE1 抑制剂,也可微弱抑制 Myt1,IC50 值分别为 24 和 72 nM。PD0166285 dihydrochloride 对 Chk1 的 IC50 值为3.433 μM。
IC50: 24 nM (WEE1), 72 nM (Myt1), 3.433 μM (Chk1).
PD0166285 (0.5 μM) dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines.
PD0166285 sensitizes radiation-induced cell killing in p53 mutant HT29 cells and in the E6-transfected, p53-null ovarian cancer cell line PA-1 but to a lesser extent in p53 wild-type PA-1 cells. PD0166285 abrogates irradiation-induced G2 arrest and significantly increases mitotic cell populations.
PD0166285 acts as a radiosensitizer to sensitize cells to radiation-induced cell death with a sensitivity enhancement ratio of 1.23.
Western Blot Analysis
Cell Line:
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Human and mouse cancer cell lines (HCT116, HT29, DLD-1, HCT8, H460, HeLa, C 26).
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Concentration:
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0.5 μM.
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Incubation Time:
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4 h.
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Result:
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Inhibited Cdc2Y15 and CdcT14 phosphorylation.
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Animal Model:
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Wild-type, Abcg2
-/-
, Abcb1a/b
-/-
and Abcb1a/b;Abcg2
-/-
FVB mice.
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Dosage:
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5 mg/kg.
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Administration:
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IV.
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Result:
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C
max
is about 400 ng/mL.
P-gp, but not BCRP, limited the brain penetration of PD0166285.
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6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
上下游产品信息
上游原料
下游产品
6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
生产厂家
212391-63-4, 6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐 相关搜索:
- Protein Kinase Inhibitors and Activators
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- C26H29Cl4N5O2
- C25H27Cl2N5O22HCl
- C26H27Cl2N5O22HCl
- PD 166285 双盐酸盐
- 6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
- 212391-63-4
- PD0166285 dihydrochloride
- PD 166285 ISO 9001:2015 REACH
- Pyrido[2,3-d]pyrimidin-7(8H)-one,6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-,hydrochloride(1:2)
- 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride
- PD 166285 - CAS 212391-63-4 - Calbiochem
- 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
- 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi
- 6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride
- PD 166285 dihydrochloride
- 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-onedihydrochloride
- PD 166285
- 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride