FG-7142
|
|
|
- CAS号:
- 78538-74-6
- 英文名:
- N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE
- 英文别名:
- LSU-65;FG 7142;Zk-31906;ZK 39106;β-CCA methylamide;N-Methyl-β-carboline-3-carboxamide;N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE;B-carboline-3-carboxylic acid N-*methylamide;4-b)indole-3-carboxamide,n-methyl-9h-pyrido(;n-methyl-9h-pyrido(3,4-b)indole-3-carboxamide
- 中文名:
- FG-7142
- 中文别名:
- 化合物FG 7142;FG 7142,苯二氮卓类反向激动剂;N-甲基-9H-吡啶[3,4-B]吲哚-3-甲酰胺;Β-CARBOLINE-3-CARBOXYLIC ACID N-METHYLAMIDE
- CBNumber:
- CB9228957
- 分子式:
- C13H11N3O
- 分子量:
- 225.25
- MOL File:
- 78538-74-6.mol
|
|
|
FG-7142化学性质
-
沸点:
-
576.3±30.0 °C(Predicted)
-
|
-
密度:
-
1.328±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
ethanol: 1 mg/mL
-
|
-
形态:
-
A crystalline solid
-
|
-
酸度系数(pKa):
-
13.44±0.46(Predicted)
-
|
-
颜色:
-
light tan
-
|
FG-7142性质、用途与生产工艺
FG 7142 (ZK 39106; LSU-65) 是一种非选择性的苯二氮杂卓反向激动剂，对含 α1 亚基的 GABAA receptor 具有高亲和力 (Ki= 91 nM)。FG 7142 (ZK 39106; LSU-65) 还调节表达 α1 亚基的 GABAA 受体上 GABA 诱导的氯通量 (EC50= 137 nM)。FG 7142 (ZK 39106; LSU-65) 可以增加酪氨酸羟化并导致小鼠大脑皮层中 β-肾上腺素受体的上调。
Ki: 91 nM (GABAA receptor)
FG-7142 has affinity for those expressing the α subunit, the K
i
values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively.
FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC
50
= 137 nM) as compared to the other α subunits (EC
50
: α2= 507 nM,α3=1.021μM , α5=1.439 μM).
FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats.
FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.
FG-7142
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100991 | FG-7142
FG 7142 | 78538-74-6 | 2mg | 500元 |
| 2024/01/25 | HY-100991 | FG-7142
FG 7142 | 78538-74-6 | 5mg | 1000元 |
FG-7142
生产厂家
全球有 58家供应商
FG-7142国内生产厂家
78538-74-6, FG-7142 相关搜索:
- GABA/Glycine receptor
- 蛋白质电泳和蛋白质印迹
- FG 7142,苯二氮卓类反向激动剂
- N-甲基-9H-吡啶[3,4-B]吲哚-3-甲酰胺
- 化合物FG 7142
- Β-CARBOLINE-3-CARBOXYLIC ACID N-METHYLAMIDE
- 78538-74-6
- ZK39106,nucleus accumben,inverse agonist,GABA Receptor,LSU65,LSU 65,dopaminergic,FG 7142,GABAA receptor,inhibit,FG-7142,Gamma-aminobutyric acid Receptor,ZK-39106,FG7142,tyrosine hydroxylase,γ-Aminobutyric acid Receptor,Inhibitor
- N-Methyl-β-carboline-3-carboxamide
- ZK 39106
- LSU-65
- 9H-beta-Carboline-3-carboxylic acid methylamide
- β-CCA methylamide
- Zk-31906
- 9H-Pyrido(3,4-B)indole-3-carboxamide, N-methyl-
- β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide
- β-Carboline-3-carboxylic acid N-methylamide
- beta-carboline-3-carboxylic acid N-methylamide
- N-METHYL-B-CARBOLINE-3-CARBOXAMIDE (FG-7 142)
- B-carboline-3-carboxylic acid N-*methylamide
- N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE
- FG 7142
- n-methyl-9h-pyrido(3,4-b)indole-3-carboxamide
- 4-b)indole-3-carboxamide,n-methyl-9h-pyrido(