4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
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- CAS号:
- 402473-54-5
- 英文名:
- ONO-AE3-208
- 英文别名:
- AE 3-208;ONO-AE3-208;AE 3-208;ONO AE3 208;ONO-AE3-208;AE 3-208;ONO AE3 208;4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid;4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid;4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid;Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
- 中文名:
- 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
- 中文别名:
- ONO-AE3-208中间体;ONO-AE3-208,性EP4拮抗剂;4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
- CBNumber:
- CB92473788
- 分子式:
- C24H21FN2O3
- 分子量:
- 404.43
- MOL File:
- 402473-54-5.mol
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4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸化学性质
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沸点:
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662.4±55.0 °C(Predicted)
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密度:
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1.30
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储存条件:
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-20°C
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溶解度:
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≥40.4 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥8.1 mg/mL in EtOH with gentle warming and ultrasonic
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酸度系数(pKa):
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4.69±0.10(Predicted)
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形态:
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powder
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颜色:
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white to beige
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4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸性质、用途与生产工艺
ONO-AE3-208 是一种 EP4 拮抗剂，能够抑制前列腺癌细胞的侵袭，迁移与代谢。
ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.
ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.
4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-50901 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
ONO-AE3-208 | 402473-54-5 | 2mg | 850元 |
| 2024/01/25 | HY-50901 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
ONO-AE3-208 | 402473-54-5 | 10mM * 1mLin DMSO | 1157元 |
4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
生产厂家
402473-54-5, 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 相关搜索:
对氨基苯磺酸 氰基硼氢化钠 氰基丙烯酸乙酯 (3E,5S)-5-(羟基甲基)-3-[(1S,2R,4AS,6R,8AR)-羟基[1,2,4A,5,6,7,8,8A-八氢-1,3,6-三甲基-2-(1E)-1-丙烯-1-基-1-萘基]亚甲基]-1-甲基-2,4-吡咯烷二酮 GW627368X 4-[(1S)-1-[[5-氯-2-(4-氟苯氧基)苄基]氨基]乙基]苯甲酸 GRAPIPRANT
- 合成有机化合物配体
- 化合物
- G蛋白偶联受体&G蛋白
- ONO-AE3-208,性EP4拮抗剂
- ONO-AE3-208中间体
- 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
- 402473-54-5
- 4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid
- 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid
- Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
- AE 3-208;ONO AE3 208
- ONO-AE3-208;AE 3-208;ONO AE3 208
- AE 3-208
- ONO-AE3-208
- 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid