ALSTONINE
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- CAS号:
- 642-18-2
- 英文名:
- Indole alkaloid
- 英文别名:
- Aids002662;Aids-002662;3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium;Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)-
- 中文名:
- ALSTONINE
- 中文别名:
- 鸭脚木碱,鸡骨常山碱
- CBNumber:
- CB92493188
- 分子式:
- C21H20N2O3
- 分子量:
- 348.4
- MOL File:
- 642-18-2.mol
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ALSTONINE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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ALSTONINE性质、用途与生产工艺
Alstonine 是一种植物性药物的主要吲哚生物碱化合物。Alstonine 具有抗精神病，抗焦虑，抗癌和抗疟疾的特性。
Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.
In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg.
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages.
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.
ALSTONINE
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642-18-2, ALSTONINE 相关搜索:
- 标准品 -中药标准品
- 生物碱
- 鸭脚木碱,鸡骨常山碱
- 642-18-2
- Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)-
- 3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium
- Aids-002662
- Aids002662