帕奎莫德
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- CAS号:
- 248282-01-1
- 英文名:
- Paquinimod
- 英文别名:
- ABR25757;ABR-25757;ABR 25757;ABR?215757;Paquinimod;ABR?215757; ABR 215757; ABR215757; PAQUINIMOD.;ABR-25757,Inhibitor,ABR25757,inhibit,Paquinimod;ABR 25757;ABR-25757;ABR25757;PAQUINIMOD;248282-01-1;N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide;N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- 中文名:
- 帕奎莫德
- 中文别名:
- 帕奎莫德;化合物PAQUINIMOD;N,5-二乙基-4-羟基-1-甲基-2-氧代-N-苯基-1,2-二氢喹啉-3-甲酰胺
- CBNumber:
- CB92498835
- 分子式:
- C21H22N2O3
- 分子量:
- 350.41
- MOL File:
- 248282-01-1.mol
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帕奎莫德化学性质
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沸点:
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487.3±45.0 °C(Predicted)
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密度:
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1.267±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO:15.0(Max Conc. mg/mL);42.8(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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4.50±1.00(Predicted)
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帕奎莫德性质、用途与生产工艺
Paquinimod (ABR 25757) 是一种 S100A8/S100A9 的特异性抑制剂，通过降低 SARS-CoV-2 感染小鼠的病毒载量来用于肺炎的研究。
S100A9 is a calcium-binding protein of the S100 family. Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. Prophylactic treatment with S100A9 inhibitor Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Paquinimod is a potent inhibitor of insulitis and diabetes development in the NOD mouse. To assess the preventive efficacy of Paquinimod on diabetes development in female NOD mice, groups of mice are treated with daily doses of 0.04, 0.2, 1, and 5 mg/kg/day of Paquinimod from week 10 of age until week 20 of age. Glycosuria is analyzed on a weekly basis from 10 weeks of age until the endpoint of the experiment at 40 weeks of age. There is a clear dose-dependent reduction in diabetes development in the Paquinimod-treated mice.
帕奎莫德
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100442 | Paquinimod | | 5 mg | 930元 |
| 2024/01/25 | HY-100442 | 帕奎莫德
Paquinimod | 248282-01-1 | 10mM * 1mLin DMSO | 1020元 |
248282-01-1, 帕奎莫德 相关搜索:
- 化合物PAQUINIMOD
- N,5-二乙基-4-羟基-1-甲基-2-氧代-N-苯基-1,2-二氢喹啉-3-甲酰胺
- 帕奎莫德
- 248282-01-1
- ABR-25757,Inhibitor,ABR25757,inhibit,Paquinimod
- 3-Quinolinecarboxamide, N,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-
- N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
- ABR?215757; ABR 215757; ABR215757; PAQUINIMOD.
- ABR-25757
- ABR25757
- ABR 25757;ABR-25757;ABR25757;PAQUINIMOD;248282-01-1
- ABR 25757
- N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- ABR?215757
- Paquinimod