(+)-沙利度胺
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- CAS号:
- 2614-06-4
- 英文名:
- (R)-(+)-THALIDOMIDE
- 英文别名:
- NSC 91729;(+)-Thalidomide;(R)-(+)-THALIDOMIDE;Thalidomide (R)-Isomer;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
- 中文名:
- (+)-沙利度胺
- 中文别名:
- (+)-沙利度胺;酞咪呱啶酮(反应停);(R)-(+)-萨力多胺;(R)-(+)-THALIDOMIDE[干冰运输]
- CBNumber:
- CB9251689
- 分子式:
- C13H10N2O4
- 分子量:
- 258.23
- MOL File:
- 2614-06-4.mol
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(+)-沙利度胺化学性质
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熔点:
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269-271°C
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沸点:
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401.48°C (rough estimate)
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密度:
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1.2944 (rough estimate)
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折射率:
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1.5300 (estimate)
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO: soluble
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形态:
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solid
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酸度系数(pKa):
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10.70±0.40(Predicted)
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颜色:
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white
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(+)-沙利度胺性质、用途与生产工艺
(R)-Thalidomide ((R)-(+)-Thalidomide) 是 Thalidomide 的 R-对映异构体。(R)-Thalidomide 具有镇静作用。
The transport of the (R)-Thalidomide from the R-imprinted MIP-1 through the donor phase to the receiver phase is much less owing to the stronger retention of the thalidomide in the organic phase. With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities.
The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs.
Adult female F344 rats are implanted with 9L gliosarcoma tumours intracranially, subcutaneously (flank), or both. Effectiveness of oral thalidomide alone, and with intraperitoneal BCNU or cisplatin combination chemotherapy, is assessed after several weeks treatment. Both serum and tissue concentrations of (R)-thalidomide are 40-50% greater than those of (S)-thalidomide. Co-administration of BCNU or cisplatin with thalidomide did not alter the concentration enantioselectivity.
(+)-沙利度胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14658B | (R)-Thalidomide | | 5 mg | 1729元 |
| 2024/01/25 | HY-14658B | (R)-Thalidomide | | 10 mg | 2765元 |
(+)-沙利度胺
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2614-06-4, (+)-沙利度胺 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- 生化试剂
- Cytoskeleton and Extracellular Matrix
- Extracellular Matrix
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Angiogenesis Regulators
- 2614-6-4
- 6/4/2614
- (R)-(+)-萨力多胺
- (R)-(+)-THALIDOMIDE[干冰运输]
- (+)-沙利度胺
- 酞咪呱啶酮(反应停)
- 2614-06-4
- (+)-Thalidomide
- 1H-Isoindole-1,3(2H)-dione, 2-[(3R)-2,6-dioxo-3-piperidinyl]-
- Thalidomide (R)-Isomer
- 2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione
- NSC 91729
- N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide
- (3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
- (+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide
- (+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione
- 6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid
- 6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2
- (R)-(+)-THALIDOMIDE
- R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE
- (R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE