CP466722
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- CAS号:
- 1080622-86-1
- 英文名:
- CP466722
- 英文别名:
- CS-73;CP466722;CP-466722, >98%;CP-466722;CP466722;CP466722 USP/EP/BP;CP466722 >=98% (HPLC);CP466722;CP 466722;CP-466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine
- 中文名:
- CP466722
- 中文别名:
- 化合物CP466722;CP-466722,ATM抑制剂;ATM激酶抑制剂(CP-466722);1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺
- CBNumber:
- CB92535567
- 分子式:
- C17H15N7O2
- 分子量:
- 349.35
- MOL File:
- 1080622-86-1.mol
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CP466722化学性质
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沸点:
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642.3±65.0 °C(Predicted)
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密度:
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1.48
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble0.5mg/mL, clear (warmed)
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酸度系数(pKa):
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0.00±0.19(Predicted)
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形态:
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powder
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颜色:
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white to beige
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CP466722性质、用途与生产工艺
CP-466722是一种有效的,可逆的ATM抑制剂,不影响ATR,且抑制PI3K或PIKK家族成员。
In vitro, CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1–101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases. In HeLa cells, CP-466722 at doses of 6μM, results in the inhibition in ATM-dependent phosphorylation by reversibly inhibiting ionizing radiation (IR)-induced ATM kinase activity. Besides, ATM-dependent p53 induction is also inhibited by CP-466722 in MCF-7 human breast cancer cells and primary and immortalized diploid human fibroblasts. In response to IR, CP-466722 increased proportion of cells with G2/M DNA content and reduces proportion of cells with G1-phase DNA content in HeLa cells. Transient exposure to CP-466722 for a period of 4 hours sensitizes HeLa cells to IR without affecting cell plating nor cell viability.
CP466722
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-11002 | CP466722 CP-466722 | 1080622-86-1 | 5mg | 800元 |
2024/01/25 | HY-11002 | CP466722 CP-466722 | 1080622-86-1 | 10mg | 1400元 |
1080622-86-1, CP466722 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- DNA损伤
- C17H15N7O2
- CP-466722,ATM抑制剂
- 化合物CP466722
- ATM激酶抑制剂(CP-466722)
- 1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺
- 1080622-86-1
- CP466722 USP/EP/BP
- CP466722 >=98% (HPLC)
- 1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-
- CP-466722, >98%
- CS-73
- CP466722;CP 466722;CP-466722
- 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
- CP-466722;CP466722
- 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
- 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722
- 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine
- 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine
- CP466722