GAP26
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- CAS号:
- 197250-15-0
- 英文名:
- GAP 26
- 英文别名:
- GAP 26;GAP-26; GAP26;Gap26 trifluoroacetate;43Gap 26, Connexin Mimetic;M.W. 1550.78 C70H107N19O19S;Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg;GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75);L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-
- 中文名:
- GAP26
- 中文别名:
- VR-13;GAP 26游离态;化合物GAP 26;穿膜肽GAP 26;间隙连接的阻断肽:GAP26;GAP26 TRIFLUOROACETATE;H-VAL-CYS-TYR-ASP-LYS-SER-PHE-PRO-ILE-SER-HIS-VAL-ARG-OH
- CBNumber:
- CB9262038
- 分子式:
- C70H107N19O19S
- 分子量:
- 1550.78
- MOL File:
- 197250-15-0.mol
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GAP26化学性质
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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insoluble in EtOH; ≥155.1 mg/mL in H2O with ultrasonic; ≥77.55 mg/mL in DMSO with gentle warming and ultrasonic
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形态:
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solid
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酸度系数(pKa):
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3.31±0.10(Predicted)
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水溶解性:
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Soluble to 2 mg/ml in water
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序列:
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H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
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GAP26性质、用途与生产工艺
Gap 26 是一种连接蛋白模拟肽，由连接蛋白connexin 43 (Cx43)的细胞外环1的残基 no. 63-75组成，是 gap junction 的抑制剂。Gap 26 可阻止光解inositol-1,4,5-trisphosphate触发的ATP释放。
| Target | Value |
gap junction
()
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Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected.
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used.
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC
50
of 28.4 ± 3.4 μM.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
GAP26
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P1082 | GAP26
Gap 26 | 197250-15-0 | 1mg | 900元 |
| 2024/01/25 | HY-P1082 | GAP26
Gap 26 | 197250-15-0 | 5mg | 1800元 |
GAP26
生产厂家
全球有 98家供应商
GAP26国内生产厂家
197250-15-0, GAP26 相关搜索:
- Various Peptides
- CancerBiology
- 药靶配体
- 多肽
- 目录多肽
- 目录肽
- C70H107N19O19S
- GAP26 TRIFLUOROACETATE
- 间隙连接的阻断肽:GAP26
- 穿膜肽GAP 26
- H-VAL-CYS-TYR-ASP-LYS-SER-PHE-PRO-ILE-SER-HIS-VAL-ARG-OH
- GAP 26游离态
- 化合物GAP 26
- VR-13
- 197250-15-0
- Gap26 trifluoroacetate
- GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75)
- L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-
- GAP-26; GAP26
- 43Gap 26, Connexin Mimetic
- Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
- M.W. 1550.78 C70H107N19O19S
- GAP 26