A 438079 (hydrochloride)
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- CAS号:
- 899431-18-6
- 英文名:
- A 438079 (hydrochloride)
- 英文别名:
- A-438079 HCl;A-438079;A438079;A 438079;3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride;P2X Receptor,A-438079,P2XRs,A 438079 hydrochloride,A438079,Inhibitor,inhibit,A 438079
- 中文名:
- A 438079 (hydrochloride)
- 中文别名:
- A-438079盐酸盐;化合物A-438079 HYDROCHLORIDE;3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶单盐酸盐
- CBNumber:
- CB92666582
- 分子式:
- C13H10Cl3N5
- 分子量:
- 342.611
- MOL File:
- 899431-18-6.mol
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A 438079 (hydrochloride)化学性质
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (>25 mg/ml)
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形态:
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solid
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颜色:
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White to off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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A 438079 (hydrochloride)性质、用途与生产工艺
A 438079 hydrochloride 是一种有效的，选择性的 P2X7 受体拮抗剂，pIC50 值为 6.9。
In 1321N1 cells stably expressing rat P2X
7
receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC
50
of 321 nM. A 438079 is also selective for the P2X
7
receptor, at concentrations up to 100 μM.
A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
A 438079 (hydrochloride)
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/16 | XW89943118601 | 试剂A-438079 HCl
A-438079 HCl | | 25mg | 2090元 |
A 438079 (hydrochloride)
生产厂家
899431-18-6, A 438079 (hydrochloride) 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂，天然产物
- 小分子抑制剂
- A-438079盐酸盐
- 化合物A-438079 HYDROCHLORIDE
- 3-[[5-(2,3-二氯苯基)-1H-四唑-1-基]甲基]吡啶单盐酸盐
- 899431-18-6
- P2X Receptor,A-438079,P2XRs,A 438079 hydrochloride,A438079,Inhibitor,inhibit,A 438079
- A-438079;A438079;A 438079
- A-438079 HCl
- 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride