331862-41-0
|
|
|
- CAS号:
- 331862-41-0
- 英文名:
- IMR-1A
- 英文别名:
- IMR-1A;IMR-1A, >98%;IMR1A;IMR 1A;IMR-1A;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
- 中文名:
- 331862-41-0
- 中文别名:
- 化合物IMR-1A;NOTCH抑制剂(IMR-1A);2-(2-甲氧基-4-((4-氧代-2-硫代噻唑烷-5-亚基)甲基)苯氧基)乙酸
- CBNumber:
- CB93133188
- 分子式:
- C13H11NO5S2
- 分子量:
- 325.36
- MOL File:
- 331862-41-0.mol
|
|
|
331862-41-0化学性质
-
密度:
-
1.55±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
under inert gas (nitrogen or Argon) at 2-8°C
-
|
-
溶解度:
-
DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)-
|
-
酸度系数(pKa):
-
3.10±0.10(Predicted)
-
|
331862-41-0性质、用途与生产工艺
IMR-1A 是IMR-1的酸性代谢产物，是一种 Notch 的有效的抑制剂，IC50值为0.5 μM，Kd值为2.9 μM。IMR-1A 具有抗肿瘤活性。
| Target | Value |
Notch
(Cell-free assay)
|
0.5 μM
|
Notch
(Cell-free assay)
|
2.9 μM(Kd)
|
IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
|
Animal Model:
|
Male C57 BL/6 mice
|
|
Dosage:
|
2 mg/kg (i.v.) and 100 mg/kg (i.p)
|
|
Administration:
|
I.v. and i.p.
|
|
Result:
|
Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
|
331862-41-0
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100431A | IMR-1A | | 1 mg | 1200元 |
| 2024/01/25 | HY-100431A | 331862-41-0
IMR-1A | 331862-41-0 | 5mg | 3000元 |
331862-41-0, 331862-41-0 相关搜索:
- 药靶配体
- 抑制剂
- 细胞生物学试剂
- 31862-41-0
- 2-(2-甲氧基-4-((4-氧代-2-硫代噻唑烷-5-亚基)甲基)苯氧基)乙酸
- 化合物IMR-1A
- NOTCH抑制剂(IMR-1A)
- 331862-41-0
- Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite
- 2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid
- Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
- IMR-1A, >98%
- IMR1A;IMR 1A;IMR-1A
- IMR-1A