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4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
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- CAS号:
- 188343-77-3
- 英文名:
- MBP146-78
- 英文别名:
- CS-2661;MBP146-78;MBP146-78;MBP146-78;Parasite,MBP-146-78,MBP146-78,MBP146 78,inhibit,MBP14678,Inhibitor;4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine;4-[2-(4-Fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]pyridine;Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-
- 中文名:
- 4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
- 中文别名:
- 化合物MBP146-78;4-(2-(4-氟苯基)-5-(1-甲基哌啶-4-基)-1H-吡咯-3-基)吡啶;4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
- CBNumber:
- CB93133421
- 分子式:
- C21H22FN3
- 分子量:
- 335.42
- MOL File:
- 188343-77-3.mol
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4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶化学性质
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沸点:
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477.6±45.0 °C(Predicted)
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密度:
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1.164±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 7.69 mg/mL (22.93 mM)
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酸度系数(pKa):
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16.04±0.50(Predicted)
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4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶性质、用途与生产工艺
MBP146-78 是一种有效的、选择性的 cyclic GMP(cGMP)-dependent protein kinases/Protein Kinase G (PKG) 抑制剂，对弓形虫Toxoplasma gondii表现出细胞抑制活性。
MBP146-78 displays a dose-dependent inhibition of
T. gondii
tachyzoites replicating inside HFFs, with an
IC
50
of 210 nM. The suppression of lytic parasite growth by MBP146-78 is reversible. Replacement of the medium with medium lacking MBP146-78, after treatment for up to 7 days at 2 μM, results in complete lysis of HFF cell monolayers. MBP146-78 is neither toxic nor inhibitory to proliferating or confluent monolayers of HFFs at concentrations of up to 10 μM.
In infected mice that are treated with MBP146-78 at 50 mg/kg twice daily, parasites are undetectable throughout the 10-day treatment period in each of the tissues examined. However, samples from brain, spleen, and lung taken from infected treated mice reveal the presence of parasites after cessation of administration of MBP146-78, indicating that a transient asymptomatic parasite recrudescence occurs in all survivors. The ability of mice to control Toxoplasma infection after MBP146-78 treatment has been terminated suggests that the mouse immune system plays a synergistic role with chemotherapy in controlling the infection.
4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-101525 | 4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
MBP146-78 | 188343-77-3 | 1mg | 770元 |
| 2024/01/25 | HY-101525 | 4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
MBP146-78 | 188343-77-3 | 10mM * 1mLin DMSO | 922元 |
4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
生产厂家
188343-77-3, 4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶 相关搜索:
- 药靶配体
- C21H22FN3
- 4-(2-(4-氟苯基)-5-(1-甲基哌啶-4-基)-1H-吡咯-3-基)吡啶
- 化合物MBP146-78
- 4-[2-(4-氟苯基)-5-(1-甲基-4-哌啶基)-1H-吡咯-3-基]吡啶
- 188343-77-3
- Parasite,MBP-146-78,MBP146-78,MBP146 78,inhibit,MBP14678,Inhibitor
- 4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine
- CS-2661
- MBP146-78;MBP146-78
- Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-
- 4-[2-(4-Fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]pyridine
- MBP146-78