TYRPHOSTIN RG 14620
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- CAS号:
- 136831-49-7
- 英文名:
- TYRPHOSTIN RG 14620
- 英文别名:
- RG-14620;RG14620, >98%;Tyrphostin RG;TYRPHOSTIN RG 14620;RG 14620,, 136831-49-7;TYRPHOSTIN RG14620, >98%;RG 14620; RG-14620; TYRPHOSTIN RG14620;2-(3-Pyridinyl)-3-(3,5-dichlorophenyl)propenenitrile;3-(3,5-Dichlorophenyl)-2-(pyridin-3-yl)acrylonitrile;2-(3',5'-DICHLOROPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE
- 中文名:
- TYRPHOSTIN RG 14620
- 中文别名:
- 化合物RG 14620;EGFR抑制剂(RG14620);酪氨酸磷酸化抑制剂RG14620;酪氨酸磷酸化抑制剂RG14620;TYRPHOSTIN RG 14620 酪氨酸磷酸化抑制剂RG14620
- CBNumber:
- CB9314319
- 分子式:
- C14H8Cl2N2
- 分子量:
- 275.13
- MOL File:
- 136831-49-7.mol
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TYRPHOSTIN RG 14620化学性质
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熔点:
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150-151℃
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沸点:
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418.2±45.0 °C(Predicted)
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密度:
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1.355±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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DMSO: soluble
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形态:
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Solid
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酸度系数(pKa):
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2.97±0.12(Predicted)
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颜色:
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White to Light yellow
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敏感性:
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Light Sensitive
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TYRPHOSTIN RG 14620性质、用途与生产工艺
RG14620 (Tyrphostin RG14620)是一种EGFR抑制剂,可直接抑制ABCG2/BCRP的传送功能。
Target | Value |
EGFR
()
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ABCG2
()
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RG14620 inhibits colony formation (IC
50
=3 μM) and DNA synthesis (IC
50
=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC
50
=4 μM) and DNA synthesis (IC
50
=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.
RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.
TYRPHOSTIN RG 14620
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-101426 | RG14620 | | 1 mg | 220元 |
2024/01/25 | HY-101426 | TYRPHOSTIN RG 14620 RG14620 | 136831-49-7 | 5mg | 550元 |
136831-49-7, TYRPHOSTIN RG 14620 相关搜索:
- 生化试剂
- 细胞生物学试剂
- Receptor Tyrosine Kinase Inhibitors
- Kinase/Phosphatase Biology
- Epidermal Growth Factor Receptor (EGFR)
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- C14H8Cl2N2
- 化合物RG 14620
- 酪氨酸磷酸化抑制剂RG14620
- TYRPHOSTIN RG 14620 酪氨酸磷酸化抑制剂RG14620
- EGFR抑制剂(RG14620)
- 酪氨酸磷酸化抑制剂RG14620
- 136831-49-7
- HER1,Tyrphostin RG-14620,inhibit,RG14620,Inhibitor,RG-14620,EGFR,Tyrphostin RG 14620,Epidermal growth factor receptor,ErbB-1
- 3-(3,5-Dichlorophenyl)-2-(pyridin-3-yl)acrylonitrile
- 3-Pyridineacetonitrile, α-[(3,5-dichlorophenyl)methylene]-
- Tyrphostin RG
- TYRPHOSTIN RG14620, >98%
- RG14620, >98%
- RG 14620; RG-14620; TYRPHOSTIN RG14620
- 3-Pyridineacetonitrile,a-[(3,5-dichlorophenyl)methylene]-
- RG 14620,, 136831-49-7
- 2-(3-Pyridinyl)-3-(3,5-dichlorophenyl)propenenitrile
- 2-(3',5'-DICHLOROPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE
- TYRPHOSTIN RG 14620
- RG-14620