盐酸异黄连碱
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- CAS号:
- 30044-78-1
- 英文名:
- Pseudocoptisine chloride
- 英文别名:
- Isocoptisine chloride;Pseudocoptisine chloride;Isocoptisine,anti-amnestic,Pseudocoptisine chloride,cytokines,anti-inflammatory,Pseudocoptisine,pro-inflammatory,RAW 264.7,Cholinesterase (ChE),inhibit,Inhibitor
- 中文名:
- 盐酸异黄连碱
- 中文别名:
- 盐酸异黄连碱
- CBNumber:
- CB93340603
- 分子式:
- C19H14ClNO4
- 分子量:
- 355.77
- MOL File:
- 30044-78-1.mol
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盐酸异黄连碱性质、用途与生产工艺
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test.
盐酸异黄连碱
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-N6894A | Pseudocoptisine chloride | | 1 mg | 800元 |
| 2024/01/25 | HY-N6894A | 盐酸异黄连碱
Pseudocoptisine chloride | 30044-78-1 | 5mg | 2000元 |
30044-78-1, 盐酸异黄连碱 相关搜索:
- 盐酸异黄连碱
- 30044-78-1
- Isocoptisine,anti-amnestic,Pseudocoptisine chloride,cytokines,anti-inflammatory,Pseudocoptisine,pro-inflammatory,RAW 264.7,Cholinesterase (ChE),inhibit,Inhibitor
- Isocoptisine chloride
- Pseudocoptisine chloride