网站主页 >> CAS数据库列表 >> N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
|
|
|
- CAS号:
- 332108-65-3
- 英文名:
- N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
- 英文别名:
- ABMA;N-(5-Bromo-2-methoxybenzyl)adamantan-1-amine;N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine;Tricyclo[3.3.1.13,7]decan-1-amine, N-[(5-bromo-2-methoxyphenyl)methyl]-
- 中文名:
- N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
- 中文别名:
- 化合物ABMA;化合物 T10222;N-(5-溴-2-甲氧基苄基)金刚烷-1-胺
- CBNumber:
- CB93514387
- 分子式:
- C18H24BrNO
- 分子量:
- 350.29
- MOL File:
- 332108-65-3.mol
|
|
|
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine化学性质
-
沸点:
-
428.2±30.0 °C(Predicted)
-
|
-
密度:
-
1.35±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 125 mg/mL (356.85 mM)
-
|
-
酸度系数(pKa):
-
9.86±0.20(Predicted)
-
|
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine性质、用途与生产工艺
ABMA 是一种细胞内毒素和病原体的广谱抑制剂。ABMA 有效地保护细胞免受各种毒素和病原体的侵害，包括病毒，细胞内细菌和寄生虫。ABMA 选择性作用于宿主细胞晚期内体，而不是针对毒素或病原体本身，具有广谱抗感染活性。
Intracellular bacteria
Viruses
Parasite
ABMA protects cells against four bacterial toxins (
Corynebacterium diphtheriae
(DT; EC
50
of 62.9 μM),
Bacillus anthracis
(LT),
Clostridium difficile
toxin B (TcdB; EC
50
of 73.3 µM),
Clostridium sordellii
lethal toxin (TcsL; EC
50
of 86.7 μM)), three viruses (Ebola (EC
50
of 3.3 µM), rabies (EC
50
of 19.4 µM), dengue-4 virus ( EC
50
of 8.2 µM)), two species of Chlamydiales intracellular bacteria (
Simkania negevensis
and
Chlamydia trachomatis
), and the parasite
Leishmania infantum
(EC
50
of 7.1 µM) at micromolar level.
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC
50
of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.
ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD
90
of ricin.
|
Animal Model:
|
Pathogen-free female BALB/c mice (6 week-old) with ricin
|
|
Dosage:
|
2 mg/kg, 20 mg/kg, 200 mg/kg
|
|
Administration:
|
Intraperitoneal injection
|
|
Result:
|
A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.
|
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-124801 | ABMA | | 5 mg | 937元 |
| 2024/04/30 | HY-124801 | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
ABMA | 332108-65-3 | 10mg | 1500元 |
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
生产厂家
332108-65-3, N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 相关搜索:
- N-(5-溴-2-甲氧基苄基)金刚烷-1-胺
- 化合物ABMA
- 化合物 T10222
- 332108-65-3
- N-(5-Bromo-2-methoxybenzyl)adamantan-1-amine
- Tricyclo[3.3.1.13,7]decan-1-amine, N-[(5-bromo-2-methoxyphenyl)methyl]-
- ABMA
- N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine