克他命
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- CAS号:
- 104104-50-9
- 英文名:
- SR-95531
- 英文别名:
- GABAZINE;SR-95531;GABAZINE BROMIDE;SR 95531 hydrobromid;SR 95531 HYDROBROMIDE;Gabazine Hydrobromide;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531);4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
- 中文名:
- 克他命
- 中文别名:
- SR-95531,GABA A拮抗剂;2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化物;4-(6-亚氨基-3-(4-甲氧苯基)哒嗪-1(6H)-基)丁酸氢溴酸盐
- CBNumber:
- CB9356638
- 分子式:
- C15H18BrN3O3
- 分子量:
- 368.23
- MOL File:
- 104104-50-9.mol
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克他命化学性质
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熔点:
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200 °C(Solv: ethanol (64-17-5))
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储存条件:
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Store at RT
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溶解度:
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DMSO: 30 mg/mL
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形态:
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solid
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颜色:
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white
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克他命性质、用途与生产工艺
Gabazine是 GABAA 受体 的选择性竞争性拮抗剂，其对 GABA 受体的 IC50 值为 ~0.2 μM。
Both bicuculline and Gabazine (SR 95531) have been characterized as competitive inhibitors of GABA binding to the GABA
A
receptor. Gabazine is more potent than bicuculline at blocking currents elicited by GABA, with an IC
50
for currents elicited by 3 μM GABA of ~0.2 μM and a Hill coefficient of 1.0. Gabazine reduces the currents elicited by 10 μM alphaxalone by ~30%, for responses of receptors containing wildtype β2 subunits. The concentration of Gabazine requires producing half the maximal block is ~0.2 μM. Gabazine also could only produce a partial block of currents gated by 300 μM pentobarbital. The maximal reduction, again, is ~30%, and the concentration of Gabazine required to produce half the maximal block is ~0.15 μM.
克他命
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104104-50-9, 克他命 相关搜索:
- GABA/Glycine receptor
- 高端化学
- GABA and Glycine Receptor Modulators
- Ligand-Gated Ion Channels
- Ion Channels
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- C15H18N3O3Br
- C15H18BrN3O3
- C15H17N3O3HBr
- 104105-50-9
- SR-95531,GABA A拮抗剂
- 4-(6-亚氨基-3-(4-甲氧苯基)哒嗪-1(6H)-基)丁酸氢溴酸盐
- 2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化物
- 104104-50-9
- Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531
- GABAZINE
- 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid
- Gabazine bromide (SR95531)
- SR 95531 hydrobromid
- SR 95531 hydrobromide NEW
- SR-95531
- SR 95531 HYDROBROMIDE
- 6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE
- 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE
- 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
- GABAZINE BROMIDE
- 4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide
- Gabazine Hydrobromide
- 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide
- 6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br
- 1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide
- Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide