化合物 T14831
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- CAS号:
- 83314-01-6
- 英文名:
- BRYOSTATIN 1
- 英文别名:
- BRYO 1;CS-1164;NSC-339555;BRYOSTATIN;Byrostatin 1;BRYOSTATIN 1;bryostatin1,0;(26R)-Bryostatin 1;Bryostatin 1 - CAS 83314-01-6 - Calbiochem;(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-y
- 中文名:
- 化合物 T14831
- 中文别名:
- 苔藓抑素1;化合物 T14831
- CBNumber:
- CB9454936
- 分子式:
- C47H68O17
- 分子量:
- 905.03
- MOL File:
- 83314-01-6.mol
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化合物 T14831化学性质
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熔点:
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230-235°
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比旋光度:
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D25 +34.1° (c = 0.044 in methanol)
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沸点:
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716.44°C (rough estimate)
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密度:
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1.1245 (rough estimate)
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折射率:
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1.5940 (estimate)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble
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酸度系数(pKa):
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11.10±0.70(Predicted)
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形态:
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solid
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颜色:
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white
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化合物 T14831性质、用途与生产工艺
Bryostatin 1 是一种天然的大环内酯类化合物，从苔藓虫 Bugula neritina 中分离出来，也是一种有效的中枢神经系统 (CNS) 渗透性的 PKC 调节剂。Bryostatin 1 以 Ki 值为 8.07 nM 和 0.45 nM 分别结合到分离的 Munc13-1 的 C1 域和全长的 Munc13-1 蛋白。Bryostatin 1 具有抗癌，抗炎，神经保护，抗 HIV-1 感染的特性。
Bryostatin 1 (1 µM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation .
The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed.
Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via toll-like receptor 4 (TLR4) through the MyD88-independent pathway, which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4
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T-helper (Th) lymphocytes into Th2 versus Th1 effector cells.
Western Blot Analysis
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Cell Line:
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HT22 cells
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Concentration:
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1 µM
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Incubation Time:
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5 minutes
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Result:
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Caused Munc13-1 to transfer to the membrane fraction.
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Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE.
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Animal Model:
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Female C57BL/6J mice (8-12-week-old) with MOG
35-55
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Dosage:
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30 μg/kg
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Administration:
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Intraperitoneal injection; 3 d per week; for 2 weeks
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Result:
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Abolished the onset of experimental autoimmune encephalomyelitis (EAE).
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化合物 T14831
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-105231 | 化合物 T14831
Bryostatin 1 | 83314-01-6 | 10μg | 5200元 |
83314-01-6, 化合物 T14831 相关搜索:
- inhibitor
- Serine/Threonine Kinase Activators
- Protein Kinase C (PKC)
- Protein Kinase ActivatorsSerine/Threonine Kinase Biology
- Kinase/Phosphatase Biology
- Cell Signaling and Neuroscience
- 对照品
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Serine/Threonine Kinase Activators
- Protein Kinase C (PKC)
- Kinase/Phosphatase Biology
- C47H68O17
- C47H68O1
- 化合物 T14831
- 苔藓抑素1
- 83314-01-6
- 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, (2E,4E)-
- Bryostatin 1 - CAS 83314-01-6 - Calbiochem
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
- CS-1164
- Byrostatin 1
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-y
- 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl2,4-octadienoicacidester
- NSC-339555
- (26R)-Bryostatin 1
- bryostatin1,0
- BRYOSTATIN
- BRYO 1
- BRYOSTATIN 1