H-THR-PHE-LEU-LEU-ARG-NH2
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- CAS号:
- 197794-83-5
- 英文名:
- TFLLR-NH2
- 英文别名:
- TFLLR;TFLLR-NH2;TFLLR-AMIDE;TFLLR-NH2(2TFA);(Thr1)-TRAP-5 amide;HYBRIDE HUMAN-XENOPE;THR-PHE-LEU-LEU-ARG-NH2;1313730-19-6/197794-83-5;H-THR-PHE-LEU-LEU-ARG-NH2;(Thr1)-PAR-1 (1-5) amide (human)
- 中文名:
- H-THR-PHE-LEU-LEU-ARG-NH2
- 中文别名:
- 血酶受体;化合物TFLLR-NH2(2TFA)
- CBNumber:
- CB9464681
- 分子式:
- C31H53N9O6
- 分子量:
- 647.81
- MOL File:
- 197794-83-5.mol
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H-THR-PHE-LEU-LEU-ARG-NH2化学性质
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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Desiccate at -20°C
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酸度系数(pKa):
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12.10±0.45(Predicted)
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形态:
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Powder
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水溶解性:
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Soluble to 1 mg/ml in water
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H-THR-PHE-LEU-LEU-ARG-NH2性质、用途与生产工艺
TFLLR-NH2是选择性的PAR1激动剂，EC50值为1.9 μM。
PAR1 agonists stimulate concentration-dependent increases in [Ca
2+
]i and in the proportions of neurones. The maximal increase in [Ca
2+
]i above basal is detected in response to 10 μm TF-NH2(peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the
in vitro
platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1
−/−
mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM.
H-THR-PHE-LEU-LEU-ARG-NH2
上下游产品信息
上游原料
下游产品
H-THR-PHE-LEU-LEU-ARG-NH2
生产厂家
197794-83-5, H-THR-PHE-LEU-LEU-ARG-NH2 相关搜索:
- Peptide Receptors
- Proteinase-activated receptor (PAR)
- 多肽
- 标准品
- C31H53N9O6
- 化合物TFLLR-NH2(2TFA)
- 血酶受体
- 197794-83-5
- (Thr?)-PAR-1 (1-5) amide (human) trifluoroacetate salt
- 1313730-19-6/197794-83-5
- TFLLR NH2 2TFA(197794 83 5(free base)),TFLLR-NH-2 2TFA(197794-83-5(free base)),TFLLRNH2 2TFA(197794835(free base))
- TFLLR-NH2 2TFA(197794-83-5(free base))
- L-Argininamide, L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-
- (Thr1)-PAR-1 (1-5) amide (human)
- TFLLR
- TFLLR-NH2(2TFA)
- (2S)-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
- REF DUPL: H-Thr-Phe-Leu-Leu-Arg-NH2
- HYBRIDE HUMAN-XENOPE
- TFLLRaMide, (Thr1)-TRAP-5 aMide, (Thr1)-PAR-1 (1-5) aMide (huMan)
- TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist
- (Thr1)-TRAP-5 amide
- TFLLR-NH2
- TFLLR-AMIDE
- THROMBIN RECEPTOR (PAR-1), HYBRIDE HUMAN-XENOPE
- THR-PHE-LEU-LEU-ARG-NH2
- H-THR-PHE-LEU-LEU-ARG-NH2