IQ 3
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- CAS号:
- 312538-03-7
- 英文名:
- IQ 3
- 英文别名:
- IQ 3;Inhibitor,IL-6,inhibit,TNF-α,IQ-3,JNK,IQ 3,IQ3,IL-1β,IL-1α;11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
- 中文名:
- IQ 3
- 中文别名:
- 化合物IQ3;IQ 3,JNK3抑制剂;11H-茚并[1,2-B]喹喔啉-11-酮 O-(2-呋喃基羰基)肟
- CBNumber:
- CB94725335
- 分子式:
- C20H11N3O3
- 分子量:
- 341.32
- MOL File:
- 312538-03-7.mol
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IQ 3化学性质
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沸点:
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573.7±58.0 °C(Predicted)
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密度:
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1.44±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 20 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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-2.84±0.20(Predicted)
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IQ 3性质、用途与生产工艺
IQ 3 是一种特定的 c-Jun N-terminal kinase (JNK) 的抑制剂，对JNK3、JNK1和JNK2的Kd值分别为66 nM、240 nM和290 nM。IQ 3 可抑制TPS1-Blue细胞中LPS诱导的 NF-κB/AP1 的转录活性，IC50值为1.4 μM。IQ 3 还可以在体外实验中抑制 TNF-α 和 IL-6 的产生。
| Target | Value |
IL-6
()
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TNF-α
()
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JNK3
(Cell-free assay)
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66 nM(Kd)
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JNK1
(Cell-free assay)
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240 nM(Kd)
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JNK2
(Cell-free assay)
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290 nM(Kd)
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IQ-3 exhibits IC
50
of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively.
IQ-3 exhibits an
IC
50
of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.
IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3.
Cell Viability Assay
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Cell Line:
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PBMCs.
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Concentration:
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0-80 μM (200 ng/mL LPS).
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Incubation Time:
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30 min.
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Result:
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Downregulated TNF-α concentration (IC
50
= 4.7 μM).
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IQ 3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-107600 | IQ 3
IQ-3 | 312538-03-7 | 5mg | 900元 |
| 2024/04/30 | HY-107600 | IQ 3
IQ-3 | 312538-03-7 | 10mM * 1mLin DMSO | 990元 |
312538-03-7, IQ 3 相关搜索:
- 药靶配体
- IQ 3,JNK3抑制剂
- 化合物IQ3
- 11H-茚并[1,2-B]喹喔啉-11-酮 O-(2-呋喃基羰基)肟
- 312538-03-7
- Inhibitor,IL-6,inhibit,TNF-α,IQ-3,JNK,IQ 3,IQ3,IL-1β,IL-1α
- 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
- IQ 3