BJE6-106
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- CAS号:
- 1564249-38-2
- 英文名:
- BJE6-106
(B106)
- 英文别名:
- B106;BJE6-106
(B106);BJE6106,BJE-6-106,BJE6 106;2H-1-Benzopyran-8-carboxaldehyde, 6-[2-(9H-carbazol-9-yl)ethyl]-2,2-dimethyl-
- 中文名:
- BJE6-106
- 中文别名:
- 化合物 T10555
- CBNumber:
- CB94844560
- 分子式:
- C26H23NO2
- 分子量:
- 381.47
- MOL File:
- 1564249-38-2.mol
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BJE6-106化学性质
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沸点:
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548.1±50.0 °C(Predicted)
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密度:
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1.16±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:50.0(Max Conc. mg/mL);131.07(Max Conc. mM)
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BJE6-106性质、用途与生产工艺
BJE6-106 (B106) 是一种有效的选择性 PKCδ 抑制剂，IC50 值为 0.05 μM，BJE6-106 (B106) 靶向 PKCδ 的选择性是 PKC 同工酶 PKCα 的 1000倍 (IC50=50 μM)。
BJE6-106 (B106) 可以诱导 caspase 依耐性细胞凋亡 (apoptosis)。BJE6-106 (B106) 具有肿瘤特异性作用。
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PKCδ
0.05 μM (IC
50
)
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PKCα
50 μM (IC
50
)
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BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations.
BJE6-106 (B106) (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells.
BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells.
Cell Viability Assay
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Cell Line:
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Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells
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Concentration:
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0.2 μM, 0.5 μM
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Incubation Time:
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24 hours, 48 hours, or 72 hours
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Result:
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Inhibited cell survival in melanoma cell lines.
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Apoptosis Analysis
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Cell Line:
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SBcl2 cells
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Concentration:
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0.2 μM, 0.5 μM
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Incubation Time:
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6 hours, 12 hours, or 24 hours
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Result:
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Induced caspase 3/7 activation.
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Western Blot Analysis
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Cell Line:
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SBcl2 cells
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Concentration:
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0.2 μM, 0.5 μM
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Incubation Time:
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2 hours, 5 hours, 10 hours
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Result:
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Increased phosphorylation of MKK4, JNK and H2AX.
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BJE6-106
上下游产品信息
上游原料
下游产品
1564249-38-2, BJE6-106 相关搜索:
- 抑制剂
- 对照品
- 化合物 T10555
- 1564249-38-2
- 2H-1-Benzopyran-8-carboxaldehyde, 6-[2-(9H-carbazol-9-yl)ethyl]-2,2-dimethyl-
- BJE6106,BJE-6-106,BJE6 106
- B106
- BJE6-106
(B106)