偶氮甲烷
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- CAS号:
- 25843-45-2
- 英文名:
- AZOXYMETHANE
- 英文别名:
- AOM;azoxy-methan;AZOXYMETHANE;CH3N=N(→O)CH3;Methane, azoxy-;ONN-Azoxydimethane;Dimethyldiazene 1-oxide;Azoxymethane
DISCONTINUED;1,2-Dimethyldiazene 1-oxide;(Z)-1,2-diMethyldiazene oxide
- 中文名:
- 偶氮甲烷
- 中文别名:
- 偶氮甲烷;氧化偶氮基甲烷;AOM氧化偶氮甲烷;偶氮甲烷(AOM);结肠癌造模诱导剂氧化偶氮甲烷;PERFEMIKER]氧化偶氮甲烷,95%
- CBNumber:
- CB9487512
- 分子式:
- C2H6N2O
- 分子量:
- 74.08
- MOL File:
- 25843-45-2.mol
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偶氮甲烷化学性质
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沸点:
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97-99 °C (lit.)
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密度:
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0.991 g/mL at 25 °C (lit.)
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折射率:
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1.4368 (estimate)
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闪点:
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24 °C
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储存条件:
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-20°C
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溶解度:
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Soluble in water, ethanol, and ether
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颜色:
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Oil
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比重:
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0.991
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EPA化学物质信息:
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Azoxymethane (25843-45-2)
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偶氮甲烷性质、用途与生产工艺
Azoxymethane 是一种结肠致癌物质，可导致 DNA 加合物的形成。
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N
7
-mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes.
Regardless of the strain, the amounts of O
6
-mG and N
7
-mG produced by Azoxymethane are highest in the liver, followed by proximal and distal colons, which have similar levels, and then by duodenum, jejunum and ileum. Results indicate that the Azoxymethane-induced DNA adduct formation in the SI and colon does not depend on bioactivation by hepatic P450 enzymes. Irrespective of the mouse strain, no aberrant crypt foci (ACF) is detected in the colons of saline-treated mice; in contrast, colonic ACF is detected in all three strains of Azoxymethane-treated mice. The Azoxymethane-treated athymic mice have approximately an 11-fold lower tumor incidence than similarly treated WT animals.
类别
有毒物品
毒性分级
高毒
急性毒性
皮下-大鼠 LD50: 27 毫克/公斤
可燃性危险特性
可燃; 燃烧产生有毒氮氧化物烟雾
储运特性
通风低温干燥; 与库房食品原料分开存放
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
偶氮甲烷
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-111375 | 偶氮甲烷
Azoxymethane | 25843-45-2 | 5mg(135mM * 500μL in Water) | 2650元 |
| 2024/01/25 | HY-111375 | Azoxymethane | | 10 mg (135 mM * 1 mL in Water) | 5000元 |
偶氮甲烷
生产厂家
全球有 60家供应商
偶氮甲烷国内生产厂家
25843-45-2, 偶氮甲烷 相关搜索:
- 高端化学
- 化工原料
- Carcinogens
- Cancer Research
- BioChemical
- CH3NN8594OCH3
- PERFEMIKER]氧化偶氮甲烷,95%
- 氧化偶氮基甲烷
- AOM氧化偶氮甲烷
- 偶氮甲烷(AOM)
- 结肠癌造模诱导剂氧化偶氮甲烷
- 偶氮甲烷
- 25843-45-2
- AOM
- "N,N-Dimethyldiazene N-oxide"
- Azoxymethane
DISCONTINUED
- (Z)-1,2-Dimethyldiazene 1-oxide
- [(E)-methyl-NNO-azoxy]methane
- (E)-dimethyldiazen-1-ium-1-olate
- AZOXYMETHANE
- Methane, azoxy-
- azoxy-methan
- 1,2-Dimethyldiazene 1-oxide
- Diazene, dimethyl-,1-oxide (9CI)
- (Z)-1,2-diMethyldiazene oxide
- CH3N=N(→O)CH3
- ONN-Azoxydimethane
- Dimethyldiazene 1-oxide
- AZOXYMETHANE, PRACTICAL GRADE, 13.4M