Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-

生物活性靶点体外研究体内研究

CAS号:: 888042-13-5

英文名:: Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-

英文别名:: GF 15;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-

中文名:: Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-

中文别名:: 化合物 T11395

CBNumber:: CB95978905

分子式:: C23H21ClO6

分子量:: 428.86

MOL File:: 888042-13-5.mol

化学性质安全信息用途供应商 4

Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-化学性质

储存条件:: Store at -20°C

溶解度:: Soluble in DMSO

安全信息

Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-性质、用途与生产工艺

生物活性

GF 15是有效的中心体聚集 (centrosomal clustering) 抑制剂，可抑制肿瘤细胞的生长。

GF 15 leads to multipolar mitosis induction with an EC ₅₀ of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC ₅₀ s of 1-5 μM.

体内研究

Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival.

Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)- 上下游产品信息

上游原料

下游产品

Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)- 生产厂家

全球有 4家供应商 Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)-国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29834	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24131	58

888042-13-5, Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-4,6-dimethoxy-6'-methyl-2'-(phenylmethoxy)-, (1'S,6'R)- 相关搜索: