色酚AS-E磷酸盐
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- CAS号:
- 18228-17-6
- 英文名:
- NAPHTHOL AS-E PHOSPHATE
- 英文别名:
- kg-501;NASEP;KD-501;NAPHTHOL AS-E PHOSPHATE;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);KG-501 (2-naphthol-AS-E-phosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY;2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
- 中文名:
- 色酚AS-E磷酸盐
- 中文别名:
- 萘酚AS-E磷酸酯;色酚AS-E磷酸盐;KG-501 磷酸萘酚AS-E;磷酸萘酚AS-E,萘酚AS-E磷酸酯,;KG-501(2-萘酚-AS-E-磷酸盐);3-((4-氯苯基)氨基甲酰基)萘-2-基磷酸二氢盐
- CBNumber:
- CB9737978
- 分子式:
- C17H13ClNO5P
- 分子量:
- 377.72
- MOL File:
- 18228-17-6.mol
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色酚AS-E磷酸盐化学性质
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密度:
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1.567±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO: soluble
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形态:
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A crystalline solid
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酸度系数(pKa):
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1.04±0.30(Predicted)
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BRN:
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6664478
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色酚AS-E磷酸盐性质、用途与生产工艺
KG-501 (2-naphthol-AS-E-phosphate)是CREB抑制剂,破坏依赖于CREB的转录(Ki=10 μM)和CREB:CBP的相互作用(Ki=50 μM)。它还能破坏磷酸化CREB(Ser-133)与KIX的结合,Ki约为90 μM。
KG-501通过阻止CREB:CBP相互作用,抑制(或部分抑制)了cAMP相关基因的诱导。KG-501抑制了神经突增生、突触发生和减少MAP2+神经细胞。
KG-501抑制CREB、CCL2的表达和ERK磷酸化,同时显著地降低了cAMP水平。CREB可能通过cAMP/ERKadjustment pathway有助于对抗神经炎症,从而保护神经。KG-501显著地促进了经氧化偶氮甲烷(AOM)处理的小鼠模型的神经功能,降低了皮质中ERK磷酸化水平和cAMP的浓度。
色酚AS-E磷酸盐
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-103299 | KG-501 | | 1 mg | 250元 |
2024/01/25 | HY-103299 | 色酚AS-E磷酸盐 KG-501 | 18228-17-6 | 5mg | 500元 |
18228-17-6, 色酚AS-E磷酸盐 相关搜索:
- API
- Substrates
- 药靶配体
- Substrates by Enzyme
- Enzymes, Inhibitors, and Substrates
- Enzyme Substrates
- Biochemicals and Reagents
- BioChemical
- C17H13ClNO5P
- 8228-17-6
- 18228-27-6
- KG-501(2-萘酚-AS-E-磷酸盐)
- 3-((4-氯苯基)氨基甲酰基)萘-2-基磷酸二氢盐
- 磷酸萘酚AS-E,萘酚AS-E磷酸酯,
- KG-501 磷酸萘酚AS-E
- 萘酚AS-E磷酸酯
- 色酚AS-E磷酸盐
- 18228-17-6
- Epigenetic Reader Domain,inhibit,Inhibitor,KG 501,Naphthol AS-E,KG501,KG-501
- kg-501
- KG-501(NaphtholAS-Ephosphate)
- 2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
- 2-naphthol-AS-E-phosphate
- NASEP
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501
- KG-501 (2-naphthol-AS-E-phosphate)
- 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)-
- 3-hydroxy-2-(hydroxymethyl)-2-methyl-1-phenyl-1-propanone
- KD-501
- [3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
- [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate
- N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide
- NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
- NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY
- N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
- NAPHTHOL AS-E PHOSPHATE