TMP920
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- CAS号:
- 1421837-45-7
- 英文名:
- TMP920
- 英文别名:
- TMP920;Benzeneacetamide, 4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-N-[(2,4-dimethylphenyl)phenylmethyl]-
- 中文名:
- TMP920
- 中文别名:
- TMP920;化合物 T17108
- CBNumber:
- CB98051762
- 分子式:
- C29H30N2O3
- 分子量:
- 454.56
- MOL File:
- 1421837-45-7.mol
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TMP920化学性质
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沸点:
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693.8±55.0 °C(Predicted)
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密度:
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1.150±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 62.5 mg/mL (137.50 mM)
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酸度系数(pKa):
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14.55±0.46(Predicted)
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TMP920性质、用途与生产工艺
TMP920 是一个高效、选择性的 RORγt 拮抗剂。TMP920 抑制 RORγt 结合 SRC1 肽的 IC50 值为 0.03 μM。
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4
+
T cells.
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro.
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro.
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets.
TMP920 significantly reduces RORγt-DNA interactions.
Cell Cytotoxicity Assay
Cell Line:
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Naïve CD4 + T cells
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Concentration:
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0.09-30 μM
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Incubation Time:
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48 hours
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Result:
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Has toxic effects on cell growth at >10 μM.
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TMP920
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-117819 | TMP920 | | 1 mg | 863元 |
2024/01/25 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 5mg | 1900元 |
1421837-45-7, TMP920 相关搜索:
- 化合物 T17108
- TMP920
- 1421837-45-7
- Benzeneacetamide, 4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-N-[(2,4-dimethylphenyl)phenylmethyl]-
- TMP920