8-OH-DPAT
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- CAS号:
- 78950-78-4
- 英文名:
- S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
- 英文别名:
- 3-(dipropylamino)tetralin-5-ol;7-(dipropylamino)tetralin-1-ol;2-(Dipropylamino)tetralin-8-ol;8-Hydroxy-2-(di-n-propylamino)tetralin;S(-)-8-Hydroxy-DPAT hydrobromide solid;7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol;(+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide;1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-;S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
- 中文名:
- 8-OH-DPAT
- 中文别名:
- 8-羟基-DPAT;化合物8-OH-DPAT
- CBNumber:
- CB9972175
- 分子式:
- C16H25NO
- 分子量:
- 247.38
- MOL File:
- 78950-78-4.mol
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8-OH-DPAT化学性质
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沸点:
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372.5±42.0 °C(Predicted)
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密度:
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1.03±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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150mg/ml in DMSO
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形态:
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solid
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酸度系数(pKa):
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10.54±0.40(Predicted)
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颜色:
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white
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旋光性 (optical activity):
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[α]25/D 67.8° in methanol(lit.)
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8-OH-DPAT性质、用途与生产工艺
8-OH-DPAT 是一种有效的,选择性的 5-HT 激动剂,对 5-HT1A 的 pIC50 值为 8.19,对 5-HT7 的 Ki 值为 466 nM,对 5-HT1B (pIC50, 5.42) 和 5-HT (pIC50 <5) 的作用很弱。
5-HT
1A
Receptor
8.19 (pIC
50
)
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5-HT
7
Receptor
466 nM (Ki)
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8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC
50
of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC
50
, 5.42), 5-HT (pIC
50
<5). 8-OH-DPAT has high affinity at 5-HT7 with a K
i
of 466 nM, and does not bind to 5-HT6 or 5-HT4.
8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice.
8-OH-DPAT
上下游产品信息
上游原料
下游产品
78950-78-4, 8-OH-DPAT 相关搜索:
- Serotonin receptor
- 合成有机化合物配体
- 8-羟基-DPAT
- 化合物8-OH-DPAT
- 78950-78-4
- 1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
- S(-)-8-Hydroxy-DPAT hydrobromide solid
- 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
- 3-(dipropylamino)tetralin-5-ol
- 8-Hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene
- 5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol
- 2-(N,N-Dipropylamino)-1,2,3,4-tetrahydronaphthalen-8-ol
- 2-(Dipropylamino)tetralin-8-ol
- 8-Hydroxy-2-(di-n-propylamino)tetralin
- 7-(dipropylamino)tetralin-1-ol
- (+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide
- S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT